Leuprolide Pregnancy and Breastfeeding Warnings
Leuprolide Pregnancy Warnings
Leuprolide has been assigned to pregnancy category X by the FDA. Animal studies have revealed evidence an increase in major fetal abnormalities, increased fetal mortality, an decreased fetal weights. There are no controlled data in human pregnancy. Inhibition of gonadotropin secretion may adversely affect pregnancy outcome. Leuprolide use during pregnancy is considered contraindicated.
The manufacturer has stated that leuprolide is contraindicated in women who are or may become pregnant while receiving the drug and that the possibility exists that spontaneous abortion may occur if the drug is administered during pregnancy. However, while not FDA approved, leuprolide has been used in the treatment of infertility. The safety of this use has not been determined. Only the short-acting subcutaneous form of leuprolide should be used in the treatment of infertility.
Leuprolide Breastfeeding Warnings
There are no data on the excretion of leuprolide into human milk. While adverse effects in the nursing infant are unlikely due to destruction of the drug in the gastrointestinal tract, milk supply may be adversely affected. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the benefit of breast-feeding to the infant and the importance of the drug to the mother.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.