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Medications for Precocious Puberty

Drugs associated with Precocious Puberty

The following drugs and medications are in some way related to, or used in the treatment of this condition.

What is Precocious Puberty: 

Precocious puberty is premature development of body characteristics that normally occur during puberty (the period in life at which rapid physical and physiologic changes occur, including development of reproductive capability). Puberty normally occurs between 13 and 15 years old in boys and between 9 and 16 years old in girls.

Females: onset of sexual development before 8 years of age including any of the following:

  • breast development
  • appearance of axillary or pubic hair
  • maturation of the external genitalia
  • onset of menses

There is some evidence that onset of development as early as 7 years of age in Caucasian girls and 6 years of age in African American girls may be considered normal.

Males: onset of sexual development before 9 years of age including any of the following:

  • enlargement of the testes and penis
  • appearance of axillary or pubic hair
  • appearance of facial hair usually first noted on the upper lip
Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Supprelin LA Rx X N 2 reviews
5.0

Generic name: histrelin systemic

Drug class: hormones/antineoplastics, gonadotropin releasing hormones

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Lupron Depot-PED Off Label Rx X N 13 reviews
6.0

Generic name: leuprolide systemic

Drug class: hormones/antineoplastics, gonadotropin releasing hormones

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
tamoxifen Rx D N Add review Add

Generic name: tamoxifen systemic

Brand names:  Nolvadex, Soltamox

Drug class: hormones/antineoplastics, selective estrogen receptor modulators

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
leuprolide Off Label Rx X N 14 reviews
6.0

Generic name: leuprolide systemic

Brand names:  Lupron Depot-PED, Viadur

Drug class: hormones/antineoplastics, gonadotropin releasing hormones

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Nolvadex Rx D N Add review Add

Generic name: tamoxifen systemic

Drug class: hormones/antineoplastics, selective estrogen receptor modulators

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Soltamox Rx D N Add review Add

Generic name: tamoxifen systemic

Drug class: hormones/antineoplastics, selective estrogen receptor modulators

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Vantas Rx X N Add review Add

Generic name: histrelin systemic

Drug class: hormones/antineoplastics, gonadotropin releasing hormones

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Synarel Rx X N Add review
2.0

Generic name: nafarelin systemic

Drug class: gonadotropin releasing hormones

For consumers: dosage, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Viadur Off Label Rx X N Add review Add

Generic name: leuprolide systemic

Drug class: hormones/antineoplastics, gonadotropin releasing hormones

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
histrelin Rx X N 2 reviews
5.0

Generic name: histrelin systemic

Brand names:  Supprelin LA, Vantas

Drug class: hormones/antineoplastics, gonadotropin releasing hormones

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
nafarelin Rx X N Add review
2.0

Generic name: nafarelin systemic

Brand name:  Synarel

Drug class: gonadotropin releasing hormones

For consumers: dosage, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
Showing all

Learn more about Precocious Puberty

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N The drug is not subject to the Controlled Substances Act.
1 The drug has a high potential for abuse. The drug has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use of the drug under medical supervision.
2 The drug has a high potential for abuse. The drug has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug may lead to severe psychological or physical dependence.
3 The drug has a potential for abuse less than the drugs in schedules 1 and 2. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to moderate or low physical dependence or high psychological dependence.
4 The drug has a low potential for abuse relative to the drugs in schedule 3. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 3.
5 The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 4.
Alcohol
X Interacts with Alcohol.

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