Vantas Side Effects

Generic Name: histrelin

Note: This page contains side effects data for the generic drug histrelin. It is possible that some of the dosage forms included below may not apply to the brand name Vantas.

It is possible that some side effects of Vantas may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to histrelin: subcutaneous implant, subcutaneous kit

As well as its needed effects, histrelin (the active ingredient contained in Vantas) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking histrelin, check with your doctor or nurse immediately:

Rare
  • Bloody urine
  • decreased frequency or amount of urine
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • nausea
  • swelling of the face, fingers, or lower legs
  • trouble with breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain
Incidence not known
  • Abdominal or stomach pain
  • bloating of the abdomen or stomach
  • dark urine
  • light-colored stools
  • seizures
  • yellow eyes or skin

Some histrelin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Decrease in testicle size
  • feeling of warmth
  • local infection, irritation, pain, redness, or swelling on the skin where the implant was placed
  • redness of the face, neck, arms, and upper chest
  • sudden sweating
Less common
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • flushing or redness of the skin
  • headache
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • sleeplessness
  • swelling of the breast or breast soreness in both females and males
  • trouble sleeping
  • unusually warm skin

For Healthcare Professionals

Applies to histrelin: subcutaneous implant, subcutaneous kit

Endocrine

Common (1% to 10%): Elevated blood glucose, gynecomastia
Uncommon (0.1% to 1%): Elevated blood lactate dehydrogenase, elevated blood testosterone
Rare (less than 0.1%): Benign pituitary tumor
Postmarketing reports: Pituitary apoplexy[Ref]

Cardiovascular

Very common (10% or more): Hot flashes (up to 65.5%)
Common (1% to 10%): Blushing
Uncommon (0.1% to 1%): Hematoma, peripheral edema
Rare (less than 0.1%): Palpitations, ventricular extrasystoles[Ref]

Local

Very common (10% or more): Implant/application site reaction (up to 51.1%)
Common (1% to 10%): Implant/application site injury, keloid scar, scar, suture-related complication, post procedural pain
Postmarketing reports: Implant breakage[Ref]

Implant/application site reactions includes discomfort, bruising, soreness, pain, tenderness, tingling, itching, erythema, inflammation, protrusion, and swelling.[Ref]

Other

Common (1% to 10%): Asthenia, fatigue
Uncommon (0.1% to 1%): Sexual dysfunction, breast pain, breast tenderness, pain (exacerbated and non specific), swelling, feeling cold, bruising, malaise
Rare (less than 0.1%): Wound infection, disease progression[Ref]

Psychiatric

Common (1% to 10%): Mood changes, depression, decreased libido, insomnia
Uncommon (0.1% to 1%): Irritability[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, pain in the extremities
Uncommon (0.1% to 1%): Back pain, muscle spasm, muscle infiltration, neck pain, bone pain, muscle twitching, myalgia[Ref]

Dermatologic

Common (1% to 10%): Contusion, hypotrichosis, hypertrichosis
Uncommon (0.1% to 1%): Night sweats, pruritus, hyperhidrosis
Rare (less than 0.1%): Skin infection[Ref]

Gastrointestinal

Common (1% to 10%): Constipation
Uncommon (0.1% to 1%): Abdominal discomfort, nausea[Ref]

Genitourinary

Common (1% to 10%): Erectile dysfunction, testicular atrophy, pollakisuria, urinary retention
Uncommon (0.1% to 1%): Male genital pruritus, dysuria, hematuria, elevated prostatic acid phosphatase, ureteral stent occlusion, urinary frequency
Rare (less than 0.1%): Dysmenorrhea, menorrhagia, metrorrhagia[Ref]

General

Supprelin LA(R):
-The most common adverse reactions involved the implant site, including bruising, pain, soreness, erythema, and swelling.[Ref]

Hematologic

Uncommon (0.1% to 1%): Anemia[Ref]

Hepatic

Common (1% to 10%): Hepatic disorder
Uncommon (0.1% to 1%): Elevated aspartate aminotransferase
Postmarketing reports: Drug-induced liver injury[Ref]

Immunologic

Rare (less than 0.1%): Influenza-like illness[Ref]

Metabolic

Common (1% to 10%): Fluid retention, hypercalcemia, hypercholesterolemia, food cravings, increased appetite, weight gain, weight loss[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Tremor, lethargy
Rare (less than 0.1%): Migraine
Postmarketing reports: Seizures/convulsions[Ref]

Renal

Common (1% to 10%): Impaired renal function
Uncommon (0.1% to 1%): Renal failure, nephrolithiasis, decreased creatinine clearance[Ref]

Respiratory

Common (1% to 10%): Exertional dyspnea
Rare (less than 0.1%): Epistaxis[Ref]

References

1. "Product Information. Vantas (histrelin)." Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.

2. "Product Information. Supprelin LA (histrelin)." Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.

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