Histrelin Side Effects

Some side effects of histrelin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to histrelin: subcutaneous implant, subcutaneous kit

Along with its needed effects, histrelin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking histrelin:

Rare
  • Bloody urine
  • decreased frequency or amount of urine
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • nausea
  • swelling of the face, fingers, or lower legs
  • trouble with breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain
Incidence not known
  • Abdominal or stomach pain
  • bloating of the abdomen or stomach
  • dark urine
  • light-colored stools
  • seizures
  • yellow eyes or skin

Some side effects of histrelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decrease in testicle size
  • feeling of warmth
  • local infection, irritation, pain, redness, or swelling on the skin where the implant was placed
  • redness of the face, neck, arms, and upper chest
  • sudden sweating
Less common
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • flushing or redness of the skin
  • headache
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • sleeplessness
  • swelling of the breast or breast soreness in both females and males
  • trouble sleeping
  • unusually warm skin

For Healthcare Professionals

Applies to histrelin: subcutaneous implant, subcutaneous kit

Genitourinary

Genitourinary side effects in pediatric patients have included breast tenderness, dysmenorrhea, gynecomastia, and, menorrhagia. Genitourinary side effects in cancer patients have included erectile dysfunction, gynecomastia, testicular atrophy, breast pain, breast tenderness, male genital pruritus, aggravated gynecomastia, and sexual dysfunction.

Local

Local side effects in pediatric patients have included implant site reaction, keloid scars, scars, suture related complications, application site pain, wound infection, erythema, and post procedural pain. Local side effects in cancer patients have included implant site reaction, bruising, pain/soreness/tenderness, erythema, and swelling. Postmarketing side effects have included implant breakage.

Nervous system

Nervous system side effects in pediatric patients have included headache, migraine, and mood swings. Nervous system side effects in cancer patients have included headache, dizziness, and tremor. Post marketing reports have included convulsions and seizures.

General

General side effects in pediatric patients have included feeling cold, benign pituitary tumor, increased weight, disease progression and influenza-like illness. General side effects in cancer patients have included feeling cold, lethargy, malaise, edema peripheral, pain, pain exacerbated, weakness, and weight decreased.

Dermatologic

Dermatologic side effects in pediatric patients have included pruritus. Dermatologic side effects in cancer patients have included contusion, hypotrichosis, night sweats, pruritus, and increased sweating.

Musculoskeletal

Musculoskeletal side effects in cancer patients have included arthralgia, back pain, back pain aggravated,
bone pain, muscle twitching, myalgia, neck pain, and pain in limbs.

Cardiovascular

Cardiovascular side effects in cancer patients have included palpitations, ventricular extrasystoles, stent occlusion, hematoma, and hot flashes.

Gastrointestinal

Gastrointestinal side effects in cancer patients have included abdominal discomfort, nausea, and constipation.

Hematologic

Hematologic side effects in cancer patients have included anemia.

Hepatic

Hepatic side effects in cancer patients have included hepatic disorder. Severe drug induced liver injury has been reported in association with histrelin.

Psychiatric

Psychiatric side effects in cancer patients have included depression and irritability.

Renal

Renal side effects in cancer patients have included renal calculus, dysuria, aggravated hematuria, aggravated renal failure, urinary frequency, aggravated urinary frequency, and urinary retention.

Respiratory

Respiratory side effects in cancer patients have included exertional dyspnea.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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