Histrelin Side Effects

Brand Names: Supprelin LA, Vantas

Please note - some side effects for Histrelin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Histrelin - for the Consumer

Histrelin Implant

Ask your health care provider any questions you may have about how to use Histrelin Implant. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Histrelin Implant:

Breast growth or tenderness; bruising, soreness, pain, tingling, itching or swelling at the insertion site; headache; weight gain.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding, severe pain, redness, or swelling at the insertion site; feeling cold; flu-like symptoms (eg, chills, cough, fever, headache, muscle aches); migraines; mood changes; nosebleeds; severe menstrual pain; spotting, or unusually heavy or prolonged menstrual periods; severe or persistent redness or itching.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Genitourinary

Genitourinary side effects in pediatric patients have included breast tenderness, dysmenorrhea, gynecomastia, and, menorrhagia. Genitourinary side effects in cancer patients have included erectile dysfunction, gynecomastia, testicular atrophy, breast pain, breast tenderness, male genital pruritus, aggravated gynecomastia, and sexual dysfunction.

Local

Local side effects in pediatric patients have included implant site reaction, keloid scars, scars, suture related complications, application site pain, wound infection, erythema, and post procedural pain. Local side effects in cancer patients have included implant site reaction, bruising, pain/soreness/tenderness, erythema, and swelling.

Nervous system

Nervous system side effects in pediatric patients have included headache, migraine, and mood swings. Nervous system side effects in cancer patients have included headache, dizziness, and tremor.

General

General side effects in pediatric patients have included feeling cold, benign pituitary tumor, increased weight, disease progression and influenza-like illness. General side effects in cancer patients have included feeling cold, lethargy, malaise, edema peripheral, pain, pain exacerbated, weakness, and weight decreased.

Dermatologic

Dermatologic side effects in pediatric patients have included pruritus. Dermatologic side effects in cancer patients have included contusion, hypotrichosis, night sweats, pruritus, and increased sweating.

Musculoskeletal

Musculoskeletal side effects in cancer patients have included arthralgia, back pain, back pain aggravated,
bone pain, muscle twitching, myalgia, neck pain, and pain in limbs.

Cardiovascular

Cardiovascular side effects in cancer patients have included palpitations, ventricular extrasystoles, stent occlusion, hematoma, and hot flashes.

Gastrointestinal

Gastrointestinal side effects in cancer patients have included abdominal discomfort, nausea, and constipation.

Hematologic

Hematologic side effects in cancer patients have included anemia.

Hepatic

Hepatic side effects in cancer patients have included hepatic disorder. Severe drug induced liver injury has been reported in association with histrelin.

Psychiatric

Psychiatric side effects in cancer patients have included depression and irritability.

Renal

Renal side effects in cancer patients have included renal calculus, dysuria, aggravated hematuria, aggravated renal failure, urinary frequency, aggravated urinary frequency, and urinary retention.

Respiratory

Respiratory side effects in cancer patients have included exertional dyspnea.

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