Histrelin Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 7, 2024.

Applies to histrelin: subcutaneous implant.

Common side effects of histrelin

Some side effects of histrelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• decrease in testicle size
• feeling of warmth
• local infection, irritation, pain, redness, or swelling on the skin where the implant was placed
• redness of the face, neck, arms, and upper chest
• sudden sweating

Less common

• decreased interest in sexual intercourse
• difficulty having a bowel movement
• flushing or redness of the skin
• headache
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• swelling of the breast or breast soreness in both females and males
• unusually warm skin

Rare

• bruising
• confusion
• constipation
• depression
• difficulty in moving
• dry mouth
• general feeling of discomfort or illness
• metallic taste
• muscle pain, stiffness, or weakness
• night sweats
• pain in the joints
• pale skin
• thirst
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Serious side effects of histrelin

Along with its needed effects, histrelin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking histrelin:

Rare

• bloody urine
• decreased frequency or amount of urine
• increased thirst
• loss of appetite
• lower back or side pain
• nausea
• swelling of the face, fingers, or lower legs
• trouble breathing
• unusual tiredness or weakness
• vomiting
• weight gain

Incidence not known

• bloating of the stomach
• blurred or double vision
• change in ability to see colors, especially blue or yellow
• dark urine
• discouragement
• dizziness
• eye pain
• feeling sad or empty
• irritability
• light-colored stools
• loss of interest or pleasure
• seizures
• severe headache
• stomach pain
• trouble concentrating
• trouble sleeping
• yellow eyes or skin

For Healthcare Professionals

Applies to histrelin: subcutaneous implant, subcutaneous kit.

Endocrine

• Common (1% to 10%): Elevated blood glucose, gynecomastia
• Uncommon (0.1% to 1%): Elevated blood lactate dehydrogenase, elevated blood testosterone
• Rare (less than 0.1%): Benign pituitary tumor
• Postmarketing reports: Pituitary apoplexy^[Ref]

Cardiovascular

• Very common (10% or more): Hot flashes (66%)
• Common (1% to 10%): Blushing
• Uncommon (0.1% to 1%): Hematoma, peripheral edema
• Rare (less than 0.1%): Palpitations, ventricular extrasystoles^[Ref]

Local

• Very common (10% or more): Implant/application site reaction (51%)
• Common (1% to 10%): Implant/application site injury, keloid scar, scar, suture-related complication, post procedural pain
• Postmarketing reports: Implant breakage^[Ref]

Implant/application site reactions includes discomfort, bruising, soreness, pain, tenderness, tingling, itching, erythema, inflammation, protrusion, and swelling.^[Ref]

Other

• Common (1% to 10%): Asthenia, fatigue
• Uncommon (0.1% to 1%): Sexual dysfunction, breast pain, breast tenderness, pain (exacerbated and non specific), swelling, feeling cold, bruising, malaise
• Rare (less than 0.1%): Wound infection, disease progression^[Ref]

Psychiatric

• Common (1% to 10%): Mood changes, depression, decreased libido, insomnia
• Uncommon (0.1% to 1%): Irritability^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, pain in the extremities
• Uncommon (0.1% to 1%): Back pain, muscle spasm, muscle infiltration, neck pain, bone pain, muscle twitching, myalgia^[Ref]

Dermatologic

• Common (1% to 10%): Contusion, hypotrichosis, hypertrichosis
• Uncommon (0.1% to 1%): Night sweats, pruritus, hyperhidrosis
• Rare (less than 0.1%): Skin infection^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation
• Uncommon (0.1% to 1%): Abdominal discomfort, nausea^[Ref]

Genitourinary

• Common (1% to 10%): Erectile dysfunction, testicular atrophy, pollakisuria, urinary retention
• Uncommon (0.1% to 1%): Male genital pruritus, dysuria, hematuria, elevated prostatic acid phosphatase, ureteral stent occlusion, urinary frequency
• Rare (less than 0.1%): Dysmenorrhea, menorrhagia, metrorrhagia^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Anemia^[Ref]

Hepatic

• Common (1% to 10%): Hepatic disorder
• Uncommon (0.1% to 1%): Elevated aspartate aminotransferase
• Postmarketing reports: Drug-induced liver injury^[Ref]

Immunologic

• Rare (less than 0.1%): Influenza-like illness^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Tremor, lethargy
• Rare (less than 0.1%): Migraine
• Postmarketing reports: Seizures/convulsions^[Ref]

Renal

• Common (1% to 10%): Impaired renal function
• Uncommon (0.1% to 1%): Renal failure, nephrolithiasis, decreased creatinine clearance^[Ref]

Respiratory

• Common (1% to 10%): Exertional dyspnea
• Rare (less than 0.1%): Epistaxis^[Ref]

Frequently asked questions

• Is Supprelin LA the same as Lupron?
• How quickly does Supprelin LA work?

Further information

Histrelin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer