Histrelin Side Effects

Not all side effects for histrelin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to histrelin: subcutaneous implant, subcutaneous kit

In addition to its needed effects, some unwanted effects may be caused by histrelin. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking histrelin, check with your doctor or nurse immediately:

Rare
  • Bloody urine
  • decreased frequency or amount of urine
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • nausea
  • swelling of the face, fingers, or lower legs
  • trouble with breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain
Incidence not known
  • Abdominal or stomach pain
  • bloating of the abdomen or stomach
  • dark urine
  • light-colored stools
  • seizures
  • yellow eyes or skin

Some of the side effects that can occur with histrelin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Decrease in testicle size
  • feeling of warmth
  • local infection, irritation, pain, redness, or swelling on the skin where the implant was placed
  • redness of the face, neck, arms, and upper chest
  • sudden sweating
Less common
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • flushing or redness of the skin
  • headache
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • sleeplessness
  • swelling of the breast or breast soreness in both females and males
  • trouble sleeping
  • unusually warm skin

For Healthcare Professionals

Applies to histrelin: subcutaneous implant, subcutaneous kit

Endocrine

Common (1% to 10%): Elevated blood glucose, gynecomastia
Uncommon (0.1% to 1%): Elevated blood lactate dehydrogenase, elevated blood testosterone
Rare (less than 0.1%): Benign pituitary tumor
Postmarketing reports: Pituitary apoplexy

Cardiovascular

Very common (10% or more): Hot flashes (up to 65.5%)
Common (1% to 10%): Blushing
Uncommon (0.1% to 1%): Hematoma, peripheral edema
Rare (less than 0.1%): Palpitations, ventricular extrasystoles

Local

Very common (10% or more): Implant/application site reaction (up to 51.1%)
Common (1% to 10%): Implant/application site injury, keloid scar, scar, suture-related complication, post procedural pain
Postmarketing reports: Implant breakage

Implant/application site reactions includes discomfort, bruising, soreness, pain, tenderness, tingling, itching, erythema, inflammation, protrusion, and swelling.

Other

Common (1% to 10%): Asthenia, fatigue
Uncommon (0.1% to 1%): Sexual dysfunction, breast pain, breast tenderness, pain (exacerbated and non specific), swelling, feeling cold, bruising, malaise
Rare (less than 0.1%): Wound infection, disease progression

Psychiatric

Common (1% to 10%): Mood changes, depression, decreased libido, insomnia
Uncommon (0.1% to 1%): Irritability

Musculoskeletal

Common (1% to 10%): Arthralgia, pain in the extremities
Uncommon (0.1% to 1%): Back pain, muscle spasm, muscle infiltration, neck pain, bone pain, muscle twitching, myalgia

Dermatologic

Common (1% to 10%): Contusion, hypotrichosis, hypertrichosis
Uncommon (0.1% to 1%): Night sweats, pruritus, hyperhidrosis
Rare (less than 0.1%): Skin infection

Gastrointestinal

Common (1% to 10%): Constipation
Uncommon (0.1% to 1%): Abdominal discomfort, nausea

Genitourinary

Common (1% to 10%): Erectile dysfunction, testicular atrophy, pollakisuria, urinary retention
Uncommon (0.1% to 1%): Male genital pruritus, dysuria, hematuria, elevated prostatic acid phosphatase, ureteral stent occlusion, urinary frequency
Rare (less than 0.1%): Dysmenorrhea, menorrhagia, metrorrhagia

General

Supprelin LA(R):
-The most common adverse reactions involved the implant site, including bruising, pain, soreness, erythema, and swelling.

Hematologic

Uncommon (0.1% to 1%): Anemia

Hepatic

Common (1% to 10%): Hepatic disorder
Uncommon (0.1% to 1%): Elevated aspartate aminotransferase
Postmarketing reports: Drug-induced liver injury

Immunologic

Rare (less than 0.1%): Influenza-like illness

Metabolic

Common (1% to 10%): Fluid retention, hypercalcemia, hypercholesterolemia, food cravings, increased appetite, weight gain, weight loss

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Tremor, lethargy
Rare (less than 0.1%): Migraine
Postmarketing reports: Seizures/convulsions

Renal

Common (1% to 10%): Impaired renal function
Uncommon (0.1% to 1%): Renal failure, nephrolithiasis, decreased creatinine clearance

Respiratory

Common (1% to 10%): Exertional dyspnea
Rare (less than 0.1%): Epistaxis

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web4)