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Supprelin LA Side Effects

Generic name: histrelin

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 7, 2024.

Note: This document provides detailed information about Supprelin LA Side Effects associated with histrelin. Some dosage forms listed on this page may not apply specifically to the brand name Supprelin LA.

Applies to histrelin: subcutaneous implant.

Common side effects of Supprelin LA

Some side effects of histrelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • decrease in testicle size
  • feeling of warmth
  • local infection, irritation, pain, redness, or swelling on the skin where the implant was placed
  • redness of the face, neck, arms, and upper chest
  • sudden sweating

Less common

  • decreased interest in sexual intercourse
  • difficulty having a bowel movement
  • flushing or redness of the skin
  • headache
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • swelling of the breast or breast soreness in both females and males
  • unusually warm skin

Rare

  • bruising
  • confusion
  • constipation
  • depression
  • difficulty in moving
  • dry mouth
  • general feeling of discomfort or illness
  • metallic taste
  • muscle pain, stiffness, or weakness
  • night sweats
  • pain in the joints
  • pale skin
  • thirst
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Serious side effects of Supprelin LA

Along with its needed effects, histrelin (the active ingredient contained in Supprelin LA) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking histrelin:

Rare

  • bloody urine
  • decreased frequency or amount of urine
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • nausea
  • swelling of the face, fingers, or lower legs
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Incidence not known

  • bloating of the stomach
  • blurred or double vision
  • change in ability to see colors, especially blue or yellow
  • dark urine
  • discouragement
  • dizziness
  • eye pain
  • feeling sad or empty
  • irritability
  • light-colored stools
  • loss of interest or pleasure
  • seizures
  • severe headache
  • stomach pain
  • trouble concentrating
  • trouble sleeping
  • yellow eyes or skin

For healthcare professionals

Applies to histrelin: subcutaneous implant, subcutaneous kit.

Endocrine

Cardiovascular

Local

Implant/application site reactions includes discomfort, bruising, soreness, pain, tenderness, tingling, itching, erythema, inflammation, protrusion, and swelling.[Ref]

Other

Psychiatric

Musculoskeletal

Dermatologic

Gastrointestinal

Genitourinary

Hematologic

Hepatic

Immunologic

Nervous system

Renal

Respiratory

References

1. (2010) "Product Information. Vantas (histrelin)." Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc)

2. (2010) "Product Information. Supprelin LA (histrelin)." Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc)

Frequently asked questions

Further information

Supprelin LA side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.