Tamoxifen Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Breast Cancer

For the treatment of metastatic breast cancer in women and men:
20 to 40 mg orally Dosages greater than 20 mg should be given in divided doses (morning and evening).

For the treatment of women with Ductal Carcinoma in Situ, following breast surgery and radiation:
20 mg orally daily for 5 years.

To reduce the incidence of breast cancer in women at high risk for breast cancer:
20 mg orally daily for 5 years.

Usual Adult Dose for Breast Cancer - Adjuvant

For the treatment of node-positive breast cancer in postmenopausal women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation:
10 mg orally 2 to 3 times a day for 5 years.

Usual Adult Dose for Breast Cancer-Palliative

10 to 20 mg orally twice a day

A beneficial response may not be evident for several months after initiation of therapy.

Usual Pediatric Dose for McCune-Albright Syndrome

For use in girls age 2 to 10 years with McCune-Albright Syndrome and precocious puberty:
20 mg once a day. The duration of treatment is up to 12 months.

Usual Pediatric Dose for Precocious Puberty

For use in girls age 2 to 10 years with McCune-Albright Syndrome and precocious puberty:
20 mg once a day. The duration of treatment is up to 12 months.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

One study (n=316) has reported that "Hepatic dysfunction had no obvious effect on drug concentrations, an exception being a slight reduction in the relative proportion of tamoxifen." However, the safety and efficacy of tamoxifen in patients with liver disease are not fully known. Tamoxifen undergoes extensive hepatic metabolism to active compounds. Alterations in this metabolism may affect the efficacy as well as the clearance of the drug. In addition, tamoxifen has been associated with rare cases of hepatotoxicity. Caution is recommended if tamoxifen is to be used in patients with hepatic dysfunction.

The long-term effects of tamoxifen therapy for girls have not been established.

Dialysis

Data not available

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