Generic Name: lisdexamfetamine (lis-DEX-am-FET-a-meen)
Brand Name: Vyvanse
Lisdexamfetamine has a high risk for abuse. It may be habit-forming if used for a long period of time. Use lisdexamfetamine only as prescribed. Do not share it with others. Abuse of lisdexamfetamine may cause serious heart problems, blood vessel problems, or sudden death.
Lisdexamfetamine is used for:
Treating attention deficit hyperactivity disorder (ADHD). It may also be used for other conditions as determined by your doctor.
Lisdexamfetamine is an amphetamine. Exactly how lisdexamfetamine works is not known. It affects certain chemicals in the brain that may help improve attention span and behavior.
Do NOT use lisdexamfetamine if:
- you are allergic to any ingredient in lisdexamfetamine or to similar medicines
- you have severe hardening of the arteries; active heart or blood vessel disease; moderate, severe, or uncontrolled high blood pressure; an overactive thyroid; glaucoma; or agitation, anxiety, or tension
- you have serious heart problems (eg, heart defect, irregular heartbeat)
- you have a history of alcohol or other substance abuse
- you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
- you take guanethidine or guanadrel
Contact your doctor or health care provider right away if any of these apply to you.
Before using lisdexamfetamine:
Some medical conditions may interact with lisdexamfetamine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart problems (eg, heart failure, heart defects, fast or irregular heartbeat), a recent heart attack, high blood pressure, hardening of the arteries, stroke, or blood vessel problems, or if a family member has a history of any of these problems or sudden death
- if you or a family member have a history of mental or mood problems (eg, bipolar disorder, depression, psychosis), abnormal thoughts, hallucinations, suicidal thoughts or attempts, or alcohol or other substance abuse or dependence
- if you have a history of seizures, growth problems, thyroid problems, liver or kidney problems, uncontrolled muscle movements (eg, tics), Tourette syndrome, anorexia, the blood disease porphyria, or abnormal electroencephalograms (EEGs)
Some MEDICINES MAY INTERACT with lisdexamfetamine. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Furazolidone or MAOIs (eg, phenelzine) because side effects, such as severe high blood pressure, fever, headache, and irregular heartbeat, may occur
- Alkalinizing agents (eg, acetazolamide, sodium bicarbonate), decongestants (eg, pseudoephedrine), propoxyphene, or sympathomimetics (eg, albuterol) because they may increase the risk of lisdexamfetamine's side effects
- Ascorbic acid (vitamin C), glutamic acid, haloperidol, lithium, phenothiazines (eg, chlorpromazine), reserpine, or urinary acidifiers (eg, methenamine, ammonium chloride) because they may decrease lisdexamfetamine's effectiveness
- Meperidine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine, venlafaxine), tramadol, or tricyclic antidepressants (eg, desipramine) because the risk of their side effects may be increased by lisdexamfetamine
- Antihistamines (eg, diphenhydramine), beta-blockers (eg, atenolol), certain blood pressure medicines, ethosuximide, guanadrel, guanethidine, phenobarbital, or phenytoin because their effectiveness may be decreased by lisdexamfetamine
This may not be a complete list of all interactions that may occur. Ask your health care provider if lisdexamfetamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use lisdexamfetamine:
Use lisdexamfetamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Lisdexamfetamine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get lisdexamfetamine refilled.
- Take lisdexamfetamine by mouth in the morning with or without food.
- Swallow lisdexamfetamine whole. Do not break, crush, or chew before swallowing. If you cannot swallow the capsule whole, you may open it and pour the powder into a glass of water. Using a spoon, break apart any powder that is stuck together. Stir well until the powder and water are completely mixed together. Drink the mixture right away. Do not store the mixture for future use. It is normal to see a filmy coating on the inside of your glass after you drink lisdexamfetamine.
- Take lisdexamfetamine on a regular schedule to get the most benefit from it. Taking lisdexamfetamine at the same time each day will help you remember to take it.
- If you miss a dose of lisdexamfetamine, take it as soon as possible if you remember that morning. If it is past noon, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use lisdexamfetamine.
Important safety information:
- Lisdexamfetamine may cause drowsiness, dizziness, blurred vision, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use lisdexamfetamine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Lisdexamfetamine should be used as a part of an ADHD treatment program that includes a variety of treatment measures (eg, psychological, educational, social).
- Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
- Lisdexamfetamine may cause sleeplessness. Do not take lisdexamfetamine near your bedtime unless your doctor tells you otherwise.
- Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). Caffeine may increase the side effects of lisdexamfetamine.
- Serious side effects, including heart attack, stroke, and sudden death, have occurred with the use of stimulant medicines in patients with heart defects or other serious heart problems. If you have a heart defect or other serious heart problem, talk with your doctor about other therapies to treat your condition.
- Before you start any new medicine, check the label to see if it has a decongestant in it. If it does or if you are not sure, check with your doctor or pharmacist.
- Tell your doctor or dentist that you take lisdexamfetamine before you receive any medical or dental care, emergency care, or surgery.
- Lisdexamfetamine may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking lisdexamfetamine.
- Lab tests, including blood pressure, pulse, and heart function, may be performed while you use lisdexamfetamine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Lisdexamfetamine should be used with extreme caution in CHILDREN younger than 6 years old. Safety and effectiveness in these children have not been confirmed.
- Lisdexamfetamine may affect the growth rate and weight gain in CHILDREN and teenagers in some cases. They may need regular growth and weight checks while they take lisdexamfetamine.
- PREGNANCY and BREAST-FEEDING: Lisdexamfetamine may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using lisdexamfetamine while you are pregnant. Lisdexamfetamine is found in breast milk. Do not breast-feed while taking lisdexamfetamine.
Some people who use lisdexamfetamine for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking lisdexamfetamine suddenly, you may have WITHDRAWAL symptoms. These may include severe or unusual sadness, agitation, or fatigue.
Possible side effects of lisdexamfetamine:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Decreased appetite; diarrhea; dizziness; dry mouth; headache; mild irritability; nausea; stomach pain; trouble sleeping; vomiting; weight loss.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); blurred vision or other vision changes; change in sexual ability or desire; chest, jaw, or arm pain; confusion; fainting; fast or irregular heartbeat; fever; hallucinations; new or worsening mental, mood, or behavior changes (eg, abnormal thoughts, aggression, agitation, anxiety, delusions, depression, hostility); one-sided weakness; red, swollen, blistered, or peeling skin; seizures; severe or persistent headache; shortness of breath; slurred speech; sudden, severe nausea or vomiting; tremor; uncontrolled speech or muscle movements (eg, tics); unusual sweating; unusual weakness or tiredness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; fainting; fast breathing; fever; hallucinations; irregular heartbeat; mental or mood changes (eg, depression); muscle pain or tenderness; overactive reflexes; seizures; severe nausea, vomiting, diarrhea, or stomach cramps; severe or persistent headache or dizziness; severe restlessness; tremor; unusual tiredness.Proper storage of lisdexamfetamine:
Store lisdexamfetamine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Keep in a tightly closed container. Do not store in the bathroom. Keep lisdexamfetamine out of the reach of children and away from pets.
- If you have any questions about lisdexamfetamine, please talk with your doctor, pharmacist, or other health care provider.
- Lisdexamfetamine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take lisdexamfetamine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about lisdexamfetamine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to lisdexamfetamine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using lisdexamfetamine.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.