Lisdexamfetamine Side Effects
It is possible that some side effects of lisdexamfetamine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to lisdexamfetamine: oral capsule
As well as its needed effects, lisdexamfetamine may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking lisdexamfetamine, check with your doctor immediately:Less common
- Uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)
- Blistering, peeling, or loosening of the skin
- chest discomfort or pain
- difficulty with breathing
- difficulty with swallowing
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling sad or empty
- hives or welts
- joint or muscle pain
- lack of appetite
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of interest or pleasure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- redness of the skin
- skin rash
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- swelling of the feet or lower legs
- tightness in the chest
- trouble concentrating
- trouble sleeping
- twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
- unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur while taking lisdexamfetamine:Symptoms of overdose
- Abdominal or stomach cramps
- blurred vision
- change in consciousness
- dark-colored urine
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast breathing
- loss of consciousness
- muscle cramps or spasms
- muscle pain or stiffness
- overactive reflexes
- panic states
- physical attempt to injure yourself
- pounding in the ears
- seeing, hearing, or feeling things that are not there
- shakiness in the legs, arms, hands, or feet
- trembling or shaking of the hands or feet
- violent actions
Some lisdexamfetamine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Decreased appetite
- upper abdominal or stomach pain
- weight decreased
- dry mouth
- quick to react or overreact emotionally
- rapidly changing moods
- sleepiness or unusual drowsiness
For Healthcare Professionals
Applies to lisdexamfetamine: oral capsule
All side effects listed, unless otherwise noted, were reported in pediatric patients.
Other side effects have included decreased appetite (39%), headache, and pyrexia (2%).
Gastrointestinal side effects have included upper abdominal pain (12%), dry mouth (5%), nausea (6%), and vomiting (9%). Gastrointestinal side effects associated with amphetamine or lisdexamfetamine have included dryness of mouth, unpleasant taste, diarrhea, and constipation.
Metabolic side effects have included weight loss.
Nervous system side effects have included insomnia (19%), dizziness (5%), initial insomnia (4%), and somnolence (2%). Nervous system side effects associated with the use of recommended doses of amphetamine or lisdexamfetamine have included dyskinesia and seizures. Postmarketing reports have included psychotic episodes, mania, hallucination, and aggression.
Psychiatric side effects have included irritability (10%), affect lability (3%), and tic (2%). Psychiatric side effects associated with the use of recommended doses of amphetamine or lisdexamfetamine have included overstimulation, restlessness, euphoria, dysphoria, depression, tremor, and exacerbation of motor and phonic tics and Tourette syndrome. Postmarketing reports have included dermatillomania.
Dermatological side effects have included rash (3%). Dermatological side effects associated with amphetamine or lisdexamfetamine have included serious skin rashes, Stevens Johnson Syndrome, and toxic epidermal necrolysis.
Cardiovascular side effects associated with amphetamine or lisdexamfetamine have included palpitations, tachycardia, increased blood pressure, sudden death, stroke, and myocardial infarction. Cardiomyopathy has been associated with chronic amphetamine use.
Hypersensitivity reactions associated with amphetamine or lisdexamfetamine have included urticaria, angioedema, anaphylaxis, Stevens Johnson Syndrome, and toxic epidermal necrolysis.
Genitourinary side effects associated with amphetamine or lisdexamfetamine have included decreased libido (less than 2%), erectile dysfunction (less than 2%), impotence, and changes in libido. Postmarketing side effects include frequent or prolonged erections.
Ocular side effects including blurred vision have been reported.
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