Lisdexamfetamine Side Effects

Brand Names: Vyvanse

Please note - some side effects for Lisdexamfetamine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Lisdexamfetamine - for the Consumer

Lisdexamfetamine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Lisdexamfetamine:

Constipation; decreased appetite; diarrhea; dizziness; dry mouth; headache; increased sweating; mild irritability, nervousness, or restlessness; nausea; trouble sleeping; unpleasant taste; upper stomach pain; vomiting; weight loss.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; blurred vision or other vision changes; change in sexual ability or desire; chest pain; fainting; fast or irregular heartbeat; fever; hallucinations; new or worsening mental or mood changes; seizures; severe or persistent headache; severe or persistent irritability, nervousness, or restlessness; shortness of breath; tremor; uncontrolled speech or muscle movements (eg, tics); unusual weakness or tiredness.

Side Effects by Body System

General

All side effects listed, unless otherwise noted, were reported in pediatric patients.

Other

Other side effects have included decreased appetite (39%), headache, and pyrexia (2%).

Gastrointestinal

Gastrointestinal side effects have included upper abdominal pain (12%), dry mouth (5%), nausea (6%), and vomiting (9%). Gastrointestinal side effects associated with amphetamine or lisdexamfetamine have included dryness of mouth, unpleasant taste, diarrhea, and constipation.

Metabolic

Metabolic side effects have included weight loss.

Nervous system

Nervous system side effects have included insomnia (19%), dizziness (5%), initial insomnia (4%), and somnolence (2%). Nervous system side effects associated with the use of recommended doses of amphetamine or lisdexamfetamine have included dyskinesia and seizures. Postmarketing reports have included psychotic episodes, mania, hallucination, and aggression.

Psychiatric

Psychiatric side effects have included irritability (10%), affect lability (3%), and tic (2%). Psychiatric side effects associated with the use of recommended doses of amphetamine or lisdexamfetamine have included overstimulation, restlessness, euphoria, dysphoria, depression, tremor, and exacerbation of motor and phonic tics and Tourette syndrome.

Dermatologic

Dermatological side effects have included rash (3%). Dermatological side effects associated with amphetamine or lisdexamfetamine have included serious skin rashes, Stevens Johnson Syndrome, and toxic epidermal necrolysis.

Cardiovascular

Cardiovascular side effects associated with amphetamine or lisdexamfetamine have included palpitations, tachycardia, increased blood pressure, sudden death, stroke, and myocardial infarction. Cardiomyopathy has been associated with chronic amphetamine use.

Hypersensitivity

Hypersensitivity reactions associated with amphetamine or lisdexamfetamine have included urticaria, angioedema, anaphylaxis, Stevens Johnson Syndrome, and toxic epidermal necrolysis.

Genitourinary

Genitourinary side effects associated with amphetamine or lisdexamfetamine have included decreased libido (less than 2%), erectile dysfunction (less than 2%), impotence, and changes in libido.

Ocular

Ocular side effects including blurred vision have been reported.

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