Lisdexamfetamine Dosage
This dosage information may not include all the information needed to use Lisdexamfetamine safely and effectively. See additional information for Lisdexamfetamine.
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Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Attention Deficit Disorder
Initial dose: 30 mg orally once a day in the morning
If necessary, the initial daily dose may be increased by 10 mg to 20 mg approximately once a week up to a maximum daily dose of 70 mg
Usual Pediatric Dose for Attention Deficit Disorder
6 years or older:
Initial dose: 30 mg orally once a day in the morning
If necessary, the initial daily dose may be increased by 10 mg to 20 mg approximately once a week up to a maximum daily dose of 70 mg.
Lisdexamfetamine has not been studied in children under 6 years of age or adolescents. Long-term effects of amphetamines in children have not been well established. Amphetamines are not recommended for use in children under 3 years of age.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
The lowest effective dose should be prescribed.
Precautions
There are reports of extensive abuse with amphetamines. Tolerance, extreme psychological dependence and severe social disability have been reported, especially with prolonged therapy. Clinicians are advised to pay particular attention to individuals obtaining amphetamines for nontherapeutic use, distribution to others, or those who may increase the dose without first seeking medical advice. For these reasons and to decrease the possibility of an overdose, it is recommended that the smallest practical quantities be prescribed and that caution is employed patients who use other sympathomimetic drugs. Misuse of amphetamines may cause sudden death and serious cardiovascular adverse reactions.
Lisdexamfetamine is considered contraindicated for use in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, glaucoma, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, a history of drug abuse, and those patients considered to be in an agitated state. Concomitant administration of lisdexamfetamine with, or within 14 days of discontinuing treatment with, a monoamine oxidase inhibitor (MAOI) is also considered contraindicated.
There are reports of sudden death associated with central nervous system (CNS) stimulant treatment administered at usual doses to pediatric and adolescent patients with structural cardiac abnormalities or other serious heart problems. In addition, there are reports of sudden death, stroke, and myocardial infarction in adults receiving normal doses of stimulant drugs. Therefore, the use of stimulant products is not recommended in any patient with known serious structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease, or other serious cardiac problems that may place them at increased vulnerability to the sympathomimetic effects of a stimulant drug. Individuals being considered for treatment should undergo a physical examination to rule out the presence of cardiac disease and should undergo further cardiac assessment if such a condition is thought to be present. In addition a family medical history should be obtained, especially with regards to sudden death or ventricular arrhythmia. Patients who develop signs or symptoms of possible cardiac abnormalities during treatment with lisdexamfetamine should immediately undergo a complete cardiac evaluation.
Lisdexamfetamine may impair the mental abilities necessary for potentially hazardous tasks such as driving or operating machinery.
Dialysis
Data not available
Other Comments
It is not recommended to administer lisdexamfetamine in the afternoon or evening due to an increased risk of insomnia.
Lisdexamfetamine capsules may be taken whole, or the capsule may be opened and the entire contents dissolved in a glass of water. The solution should be consumed immediately and should not be stored. The dose of a single capsule should not be divided. The contents of the entire capsule should be taken, and patients should not take anything less than one capsule per day.
Where possible, drug administration should be interrupted occasionally to determine if there is a recurrence of behavioral symptoms sufficient to require continued treatment.
