amphetamine and dextroamphetaminePronunciation
Generic Name: amphetamine and dextroamphetamine (am FET a meen and DEX troe am FET a meen)
Brand Name: Adderall, Adderall XR
What is amphetamine and dextroamphetamine?
Amphetamine and dextroamphetamine are central nervous system stimulants that affect chemicals in the brain and nerves that contribute to hyperactivity and impulse control.
The combination of amphetamine and dextroamphetamine is used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD).
Amphetamine and dextroamphetamine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about amphetamine and dextroamphetamine?
You should not use this medication if you have hardened arteries (arteriosclerosis), heart disease, moderate to severe high blood pressure, overactive thyroid, glaucoma, severe anxiety or agitation, or a history of drug or alcohol addiction.
Do not use amphetamine and dextroamphetamine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
Amphetamine and dextroamphetamine may be habit forming. Never share amphetamine and dextroamphetamine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Using this medication improperly can cause death or serious side effects on the heart.
What should I discuss with my doctor before taking amphetamine and dextroamphetamine?
Do not use amphetamine and dextroamphetamine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.
You should not use this medication if you are allergic to amphetamine and dextroamphetamine or if you have:
heart disease or moderate to severe high blood pressure (hypertension);
arteriosclerosis (hardening of the arteries);
severe anxiety, tension, or agitation; or
if you have a history of drug or alcohol addiction.
To make sure amphetamine and dextroamphetamine is safe for you, tell your doctor if you have:
Tell your doctor if you have any heart problems. Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects.
high blood pressure;
heart failure, heart rhythm disorder, or recent heart attack;
a personal or family history of mental illness, psychotic disorder, bipolar illness, depression, or suicide attempt;
any drug allergies;
epilepsy or other seizure disorder; or
tics (muscle twitches) or Tourette's syndrome.
Amphetamine and dextroamphetamine may be habit forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Using this medication improperly can cause death or serious side effects on the heart.
FDA pregnancy category C. It is not known whether this medication will harm an unborn baby. It could cause premature birth, low birth weight, or withdrawal symptoms in a newborn if the mother takes amphetamine and dextroamphetamine during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Amphetamine and dextroamphetamine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medication.
Long-term use of amphetamine and dextroamphetamine can slow a child's growth. Tell your doctor if the child using this medication is not growing or gaining weight properly.
How should I take amphetamine and dextroamphetamine?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Do not take amphetamine and dextroamphetamine in the evening because it may cause sleep problems (insomnia).
Do not crush, chew, break, or open an extended-release capsule. Swallow it whole.
Your doctor will need to check your progress while you are using amphetamine and dextroamphetamine.
This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using amphetamine and dextroamphetamine.
Store at room temperature away from moisture, heat, and light.
Keep track of the amount of medicine used from each new bottle. Amphetamine and dextroamphetamine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
See also: Amphetamine and dextroamphetamine dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amphetamine and dextroamphetamine can be fatal.
What should I avoid while taking amphetamine and dextroamphetamine?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Do not take amphetamine and dextroamphetamine late in the day. A dose taken too late in the day can cause sleep problems (insomnia).
Avoid drinking fruit juices or taking vitamin C at the same time you take amphetamine and dextroamphetamine. These can make your body absorb less of the medicine.
Amphetamine and dextroamphetamine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fast, pounding, or uneven heartbeats;
pain or burning when you urinate;
talking more than usual, feelings of extreme happiness or sadness;
numbness, tingling, or strange sensations under your skin;
tremors, hallucinations, unusual behavior, or motor tics (muscle twitches); or
dangerously high blood pressure (severe headache, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Common side effects may include:
nausea, loss of appetite, stomach pain;
anxiety, agitation, mood changes, feeling nervous;
sleep problems (insomnia); or
headache, weakness, dizziness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: amphetamine and dextroamphetamine side effects (in more detail)
Amphetamine and dextroamphetamine Dosing Information
Usual Adult Dose for Narcolepsy:
Initial Dose: 10 mg per day orally upon awakening.
Maintenance Dose: The daily dosage may be increased in increments of 10 mg at weekly intervals, up to 60 mg per day in 2 to 3 divided doses. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours. If bothersome adverse reactions appear (e.g., insomnia or anorexia), dosage should be reduced.
Usual Adult Dose for Attention Deficit Disorder:
Extended Release Capsules:
Initial Dose: In adults with ADHD who are either starting treatment for the first time or switching from another medication, the recommended dose is 20 mg/day.
Usual Pediatric Dose for Narcolepsy:
<6 years: Not recommended.
6 years to 12 years:
Initial Dose: 5 mg per day orally upon awakening.
Maintenance Dose: The daily dose may be raised in increments of 5 mg at weekly intervals until optimal response is obtained, up to a maximum of 60 mg/day. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours. If bothersome adverse reactions appear (e.g., insomnia or anorexia), dosage should be reduced. Narcolepsy seldom occurs in children under 12 years of age; however, when it does, this drug may be used.
Initial Dose: 10 mg per day orally upon awakening.
Maintenance Dose: The daily dosage may be raised in increments of 10 mg at weekly intervals until optimal response is obtained, up to a maximum of 60 mg/day. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours. If bothersome adverse reactions appear (e.g., insomnia or anorexia), dosage should be reduced.
Usual Pediatric Dose for Attention Deficit Disorder:
<3 years: Not recommended.
3 to 5 years:
Initial Dose: 2.5 mg once a day orally upon awakening.
Maintenance Dose: The daily dosage may be raised in increments of 2.5 mg at weekly intervals until optimal response is obtained. Only in rare cases will it be necessary to exceed a total of 40 mg per day in 2 to 3 divided doses. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours.
>= 6 years:
Initial Dose: 5 mg once or twice a day orally upon awakening.
Maintenance Dose: The daily dosage may be raised in increments of 5 mg at weekly intervals until optimal response is obtained. Only in rare cases will it be necessary to exceed a total of 40 mg per day in 2 to 3 divided doses. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours.
Extended Release Capsules:
<6 years: Not recommended.
6 to 12 years:
Initial Dose: 5 mg to 10 mg once a day orally upon awakening.
Maintenance Dose: The daily dosage may be raised in increments of 5 mg to 10 mg at weekly intervals.
Maximum Dose: 30 mg once daily upon awakening.
13 to 17 years:
Initial Dose: 10 mg once a day orally upon awakening.
Maintenance Dose: The daily dosage may be increased to 20 mg once a day orally upon awakening after one week if ADHD symptoms are not adequately controlled.
Maximum Dose: 20 mg once daily upon awakening.
Where possible, drug administration should be interrupted occasionally to determine if there is a recurrence of behavioral symptoms sufficient to require continued therapy.
Drug treatment is not indicated in all cases of Attention Deficit Disorder with Hyperactivity and should be considered only in light of the complete history and evaluation of the child. The decision to prescribe amphetamines should depend on the physician's assessment of the chronicity and severity of the child's symptoms and their appropriateness for his/her age. Prescription should not depend solely on the presence of one or more of the behavioral characteristics. When these symptoms are associated with acute stress reactions, treatment with amphetamines is usually not indicated.
What other drugs will affect amphetamine and dextroamphetamine?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with amphetamine and dextroamphetamine, especially:
phenytoin or phenobarbital;
ammonium chloride, ascorbic acid (vitamin C), potassium phosphate;
antacids, sodium bicarbonate (Alka-Seltzer), potassium citrate, sodium citrate and citric acid, sodium citrate and potassium;
heart or blood pressure medications;
a diuretic or "water pill";
cold or allergy medicines (antihistamines);
stomach acid reducers--cimetidine, esomeprazole, famotidine, lansoprazole, nizatidine, omeprazole, ranitidine; or
an antidepressant--amitriptyline, doxepin, nortriptyline, and others.
This list is not complete. Other drugs may interact with amphetamine and dextroamphetamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More amphetamine and dextroamphetamine resources
Where can I get more information?
- Your pharmacist can provide more information about amphetamine and dextroamphetamine.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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