Trimidox (Canada)This page contains information on Trimidox for veterinary use.
The information provided typically includes the following:
- Trimidox Indications
- Warnings and cautions for Trimidox
- Direction and dosage information for Trimidox
TrimidoxThis treatment applies to the following species:
Sterile Injectable Solution
Veterinary Use Only
A clear, yellow aqueous solution for parenteral administration.
The active ingredients of TRIMIDOX are a combination of trimethoprim and sulfadoxine which has been established in a ratio of 1:5.
(Dosage Form): TRIMIDOX is a solution containing 4% W/V trimethoprim and 20% W/V sulfadoxine in an organic solvent.
Each mL contains 40 mg of trimethoprim and 200 mg of sulfadoxine.
Chlorocresol is used as a preservative at a concentration of 1mg/mL (0.1% W/V).
(Action) TRIMIDOX contains trimethoprim, a synthetic antibacterial and sulfadoxine, a sulphonamide. The two components of TRIMIDOX produce a sequential double blockade of bacterial metabolism, giving a level of activity many times greater than that obtained by either drug alone.
TRIMIDOX provides effective antibacterial activity against a wide range of infections caused by Gram-positive and Gram-negative bacteria.
TRIMIDOX has shown activity in vitro against the following organisms.
VERY SENSITIVE ORGANISMS:
Escherichia coli, Bacillus anthracis, Clostridium spp., Pasteurella spp., Shigella spp., Haemophilus influenzae, Salmonella spp., Streptococcus zooepidemicus, Proteus mirabilis, Vibrio spp.
Streptococcus viridans, Klebsiella spp., Brucella spp., Proteus spp., Enterocci spp., Actinomyces, Staphylococcus aureus (including penicillinase-producing organisms), Corynebacterium spp., Bordetella spp., Neisseria spp.
MODERATELY SENSITIVE ORGANISMS:
Enterobacter aereogenes, Nocardia spp.
Pseudomonas aeruginosa*, Leptospira spp., Mycobacterium tuberculosis, Erysipelothrix rhusiopathiae.
TRIMIDOX may be used in cattle and swine where potent systemic antibacterial action against a wide range of sensitive organisms is required.
TRIMIDOX is indicated in CATTLE for the treatment of:
RESPIRATORY TRACT INFECTIONS: Bacterial pneumonias including bovine pneumonia pasteurellosis (shipping fever).
ALIMENTARY TRACT INFECTIONS: Primarily enteric and septicaemic colibacillosis and salmonellosis.
OTHER INFECTIONS: Infectious pododermatitis (foot rot, foul in the foot) and septicaemias.
TRIMIDOX is indicated in SWINE for the treatment of:
RESPIRATORY TRACT INFECTIONS: Bacterial pneumonias.
ALIMENTARY TRACT INFECTIONS: Colibacillosis and post-weaning scours.
OTHER INFECTIONS: Mastitis-metritis-agalactia syndrome of sows (MMA) and bacterial arthritis.
Dosage and Administration
TRIMIDOX should be administered at a dose rate of 1 mL per 15 kg body weight daily. In piglets weighing less than 4.5 kg do not exceed a dose of 0.5 mL.
Intramuscular injection is recommended for cattle and swine, but if a particularly rapid response is required in acute infections TRIMIDOX can be administered by slow intravenous injection.
Treatment should continue for 2 - 3 days after symptoms have subsided. The usual course of treatment is no longer than 5 consecutive days.
TRIMIDOX should not be used in cattle or swine showing marked liver parenchymal damage or blood dyscrasias, nor in those with history of sulphonamide sensitivity.
With intravenous therapy generally, and sulphonamides in particular, hypersensitivity reactions can occur and should be appropriately treated with corticosteroids or epinephrine.
Temporary local irritation and swelling are encountered occasionally after intramuscular injection of TRIMIDOX.
Injections should not be given by routes other than those recommended.
Milk taken from treated animals during treatment and within 96 hours after the latest treatment must not be used as food. Treated animals must not be slaughtered for use in food for at least 10 days after the latest treatment with this drug.
(Adverse Reactions): No significant adverse reactions have been reported.
Store between 15°C and 25°C. Protect from light.
Available in 100 mL (code 25737), 250 mL (code 25738) and 500 mL (code 25739) vials.
Vetoquinol N.-A. Inc., 2000, ch. Georges, Lavaltrie, QC, Canada J5T 3S5
2000, CHEMIN GEORGES, LAVALTRIE, QC, J5T 3S5
|Every effort has been made to ensure the accuracy of the Trimidox information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.|
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