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Synovex LA-G (Canada)

This treatment applies to the following species:
Company: Zoetis

trenbolone acetate and estradiol benzoate extended release implants


For pasture and feedlot steers and heifers

DIN 02485125


SYNOVEX LA-G (trenbolone acetate and estradiol benzoate) is a growth promoting implant containing 150 mg of trenbolone acetate and 21 mg of estradiol benzoate with a porous polymer film coating that extends the pay-out period of the final formulation to over 200 days. Each implant consists of 6 pellets. Ten implants are provided in each cartridge.

Synovex LA-G Indications

To increase rate of weight gain for up to 200 days in steers and heifers on pasture or fed in confinement for slaughter. Product efficacy was confirmed in a growth-performance trial conducted in pasture steers and heifers weighing between 160 and 310 kg at the time of implantation and in feedlot steers and heifers weighing between 243 and 380 kg at the time of implantation.

Note: The administration of SYNOVEX LA-G implants can result in decreased marbling scores when compared to non-implanted steers and heifers.

Dosage and Administration

Pasture and Feedlot Cattle: One implant (six pellets) is administered to each steer or heifer by subcutaneous implantation in the middle one-third of the ear.

The 6 pellets which make up one implant of SYNOVEX LA-G are contained in one channel of a ten-implant cartridge. The ten-implant cartridge of SYNOVEX LA-G is designed to be used exclusively with a SYNOVEX implanting device.

Directions For Use

Implant complete contents of one cartridge cell per steer or heifer. Approved implantation technique is fully described in the fold-out carton section.

Note: Never sacrifice careful, clean technique for speed of implantation.

SYNOVEX® Applicators


For use with the applicator.

Study the following instructions carefully, then proceed step by step, until the technique becomes routine. Many head can be implanted per hour by an experienced team, one member of which should be assigned to do nothing but the implantation. Care should be taken to ensure the hands of the person administering the implant are clean and only sanitary instruments are used.

Step 1 Loading The Applicator

Load the applicator following the directions outlined in the instruction manual accompanying each applicator.

Step 2 Restraint

The animal must be confined in a restraint mechanism (squeeze chute or head gate). The implant site on the back of the ear should be prepared by scrubbing with a generous-sized piece of cotton that has been soaked in a germicidal solution.

Note: If implanting horned cattle, greater safety is provided when the head is controlled by the use of a bull lead (nose tongs).

Step 3 Implant Site

Divide the ear into three imaginary sections as illustrated. The implanted pellets should be deposited in the center one-third of the ear as shown. To accomplish this, the applicator needle should be inserted in the outer one-third of the ear as indicated by the “X” in the illustration. Implanting too close to the head may cause abnormal sexual behavior. Care should be taken to avoid severing the major arteries of the ear.

Step 4 Insert Needle

Grasp the ear with one hand. Holding the applicator firmly with the other hand, penetrate the skin at the point shown by the “X”. Thrust the needle under the skin taking care not to penetrate the cartilage. Ease the applicator forward (toward the base of the ear) until the full needle length is beneath the skin.

Step 5 Pellet Implantation

When the needle is completely inserted, activate the instrument by squeezing the trigger completely. Do not withdraw the needle, but allow the automatic needle retractor to release the pellets. This will allow the pellets to be deposited in a straight line in the path of the retracted needle.

Step 6 Inspection

Check the implant site. If properly administered, the implants should lie in a straight line under the skin.

Re-cock the gun by grasping the barrel with your left hand and lifting the cocking bolt with your right hand. Fully retract the bolt to the rear of the device. Then, return the bolt forward to its locked position. Disinfect the applicator needle in a germicidal solution. The applicator is now ready to implant the next animal.


For use in pasture and feedlot steers and pasture heifers only. Do not use in heifers intended for subsequent breeding.


No withdrawal period is required when treated according to the label.

Do not use in calves to be processed for veal.

Do not use in dairy cattle.

Implant pellets in ear only. Do not attempt to salvage the implanted site for human or animal food.

Keep out of reach of children.

Adverse Reactions

Although all adverse reactions are not reported, the following information is based on voluntary post-approval drug experience reporting. It is generally recognized that this results in significant under-reporting. The adverse events listed here reflect reporting and not necessarily causality. Bulling or riding behavior has been reported rarely with use of this product. Vaginal and rectal prolapse, udder development, ventral edema and elevated tailheads have also been reported.


Store unopened product between 20 and 25°C with excursions between 15 and 30°C. Avoid excessive heat and humidity. Once the pouch is opened, unused product may be stored in the end-folded pouch (away from light) for up to six months at 2-8°C or at 15-30°C for up to one month.

Zoetis® and Synovex are registered trademarks of Zoetis or its licensors.

Zoetis Canada Inc., Kirkland QC H9H 4M7

NET 10 cartridges of 10 doses (100 implants)



CPN: 1198565.1

Order Desk:   800-663-8888
Technical Services Canada:   800-461-0917
Technical Services USA:   800-366-5288
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