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Pyramid 3

This page contains information on Pyramid 3 for veterinary use.
The information provided typically includes the following:
  • Pyramid 3 Indications
  • Warnings and cautions for Pyramid 3
  • Direction and dosage information for Pyramid 3

Pyramid 3

This treatment applies to the following species:
Company: Boehringer Ingelheim Animal Health

Bovine Rhinotracheitis-Virus Diarrhea Vaccine

Modified Live Virus

with Metastim®

For use in animals only


Pyramid 3 Indications

This product has been shown to be effective for the vaccination of healthy cattle, including pregnant cows, against infectious bovine rhinotracheitis (IBR) and bovine virus diarrhea types 1 and 2 (BVD1 & BVD2). This product was licensed prior to the requirement to establish a minimum age for use. The duration of immunity against respiratory disease due to BVD type 1b is at least 217 days. The duration for the remaining organisms has not been determined. For more information regarding efficacy and safety data, go to

This product has also been shown to be effective against the development of BVD1 and BVD2 post-challenge viremia and leukopenia; and also against persistent BVD1 and BVD2 infection of the fetal calf when it is used subcutaneously in the cow or heifer 30 to 60 days pre-breeding. This vaccine may be used in pregnant cows or calves nursing pregnant cows provided the cows were vaccinated pre-breeding, according to label instructions, with any Express® FP vaccine, Pyramid 5, Pyramid 10, Pyramid 3, Pyramid 3+Presponse SQ, or Pyramid 5+Presponse SQ.


Contains IBR, BVD1, and BVD2 modified live viruses, with Metastim® adjuvant. Gentamicin, neomycin, polymyxin B, and thimerosal added as preservatives.

Directions and dosage: Aseptically rehydrate the vaccine with the accompanying diluent. Mix well. Inject one 2 mL dose subcutaneously using aseptic technique.

Protect animals from exposure for at least 14 days after vaccination. Contact your veterinarian or the manufacturer for information on revaccination frequency.

Fetal health risks associated with vaccination of pregnant animals with this vaccine cannot be unequivocally determined by clinical trials conducted for licensure. Appropriate strategies to address the risks associated with vaccine use in pregnant animals should be discussed with a veterinarian.


Store out of direct sunlight at 35-46°F (2-8°C). Do not freeze. Do not mix with other products, except as specified on the label. Use entire contents when first opened. Do not vaccinate within 21 days before slaughter. A small percentage of animals may show transient mild injection site swelling. In case of anaphylactoid reaction, administer epinephrine. In case of human exposure, contact a physician. Inactivate unused contents before disposal.

Preservatives: Gentamicin, neomycin, polymyxin B, and thimerosal.

Pyramid® and Express® are registered trademarks of Boehringer Ingelheim Animal Health USA Inc.

Metastim® is a trademark of Wyeth LLC. Used under license.

Boehringer Ingelheim Animal Health USA Inc., St. Joseph, MO 64506

Phone: 1 (888) 637-4251

VLN/PCN 124/1151.26


50 Doses/Rehydrate to 100 mL

This package contains one 50 dose vial of MLV vaccine and one 100 mL vial of diluent.


CPN: 1028315.1

Telephone:   800-325-9167
Customer Service:   800-243-0127
Fax:   816-236-2717
THIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.

Copyright © 2023 Animalytix LLC. Updated: 2023-05-30