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Tysabri: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on July 3, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Tysabri may be used to treat adults with multiple sclerosis or Crohn's disease and is given once every four weeks through an infusion center registered with the Touch Prescribing Program. A headache, fatigue, joint pain, and infections are the most common side effects reported although rarely, it may cause more serious side effects such as liver failure, severe herpes infections, or PML. It may not be suitable for people who already have a weakened immune system.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Tysabri may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Tysabri. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Tysabri interacts with over 300 medications; the majority of these interactions are considered major or moderate. Common medications that may interact with Tysabri include:

Tysabri may have additive immune-suppressing effects when given with any other medications such as anticancer drugs, immune-modulating, or immunosuppressive therapies, which may increase a person's risk for infection.

Do not use it in combination with other immunosuppressants such as 6-mercaptopurine, azathioprine, cyclosporine, methotrexate, or inhibitors of TNF-α.

Note that this list is not all-inclusive and includes only common medications that may interact with Tysabri. You should refer to the prescribing information for Tysabri for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Tysabri only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: July 3, 2023.