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Sutent: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 2, 2024.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Sutent is an oral capsule that may be taken once daily to treat certain types of RCC and other advanced cancers. It may be taken every day or for 4 weeks on, 2 weeks off schedule. It has been associated with some serious side effects such as liver damage, severe bleeding, cardiovascular events, and osteonecrosis of the jaw. It may cause a yellow tinge to the skin and lighten hair color.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Sutent may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Sutent. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Sutent interacts with over 380 medications; the majority of these interactions are considered moderate or major. Common medications that may interact with Sutent include:

Sutent may prolong the QT interval and this risk is higher in people taking other QT-prolonging medications, such as citalopram, chlorpromazine, haloperidol, methadone, or erythromycin.

Strong CYP3A4 enzyme inhibitors, such as ketoconazole, diltiazem, itraconazole, or grapefruit may increase blood concentrations of Sutent and its active metabolite by up to 49% and 51%, respectively.

Strong CYP3A4 enzyme inducers, such as carbamazepine, rifampicin, phenytoin, phenobarbital, and St. John’s wort, have been shown to decrease blood concentrations of Sutent and its metabolite by approximately 23% and 46% respectively. Select an alternate concomitant medication with no or minimal enzyme induction potential if possible. If coadministration cannot be avoided, consider a dose increase for Sutent to a maximum dosage of 87.5 mg orally once daily (Schedule 4/2) for GIST and RCC, and 62.5mg once daily for pNET.

Note that this list is not all-inclusive and includes only common medications that may interact with Sutent. You should refer to the prescribing information for Sutent for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sutent only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: January 1, 2024.