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Mavenclad Patient Tips

Medically reviewed by Carmen Pope, BPharm. Last updated on Aug 22, 2025.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Mavenclad is used to treat relapsing forms of MS, to include relapsing-remitting disease and active secondary progressive disease, in adults. Because of its safety profile it is usually reserved for those who have had an inadequate response to, or who are unable to tolerate other medications for MS. Upper respiratory tract infections, a headache, and decreased white blood cell counts are the most common side effects reported. 11% of patients reported hypersensitivity reactions.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Mavenclad may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Mavenclad. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Mavenclad interacts with over 390 medications; the majority of these interactions are considered major or moderate. Common medications that may interact with Mavenclad include:

Mavenclad can bind to other medications, vitamins, and herbs. Take Mavenclad three hours away from other medications.

Avoid coadministration with potent ENT1, CNT3, or BCRP transporter inhibitors such as ritonavir, eltrombopag, curcumin, cyclosporine, dilazep, nifedipine, nimodipine, cilostazol, sulindac, dipyridamole, or reserpine during the 4 to 5-day treatment cycles of Mavenclad. potent BCRP or P-gp transporter inducers, such as rifampicin or St. John's Wort may also decrease Mavenclad efficacy

It is unknown if Mavenclad reduces the effectiveness of systemically acting hormonal contraceptives. Women should use a barrier method of contraception during Mavenclad cycles and for at least 4 weeks after the last dose in the treatment cycle.

Mavenclad may have additive immune-suppressing effects when given with any other medications such as anticancer drugs, immune-modulating, or immunosuppressive therapies, which may increase a person's risk for infection. Do not use in combination with other immunosuppressants such as 6-mercaptopurine, azathioprine, cyclosporine, methotrexate, or inhibitors of TNF-α.

Avoid the use of Mavenclad with other hemotoxic drugs.

Note that this list is not all-inclusive and includes only common medications that may interact with Mavenclad. You should refer to the prescribing information for Mavenclad for a complete list of interactions.

Related/similar drugs

Frequently asked questions

References

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Mavenclad only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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