Zykadia Side Effects
Generic name: ceritinib
Medically reviewed by Drugs.com. Last updated on Sep 27, 2020.
Note: This document contains side effect information about ceritinib. Some of the dosage forms listed on this page may not apply to the brand name Zykadia.
Common side effects of Zykadia include: abdominal pain, diarrhea, hyperglycemia, increased serum alanine aminotransferase, nausea, and vomiting. Other side effects include: interstitial pulmonary disease, pneumonitis, and prolonged qt interval on ecg. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to ceritinib: oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, ceritinib (the active ingredient contained in Zykadia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ceritinib:
- Blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- clay-colored stools
- dark urine
- decreased appetite
- dry mouth
- flushed, dry skin
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- itching, skin rash
- loss of appetite
- stomach pain or tenderness
- swelling of the feet or lower legs
- troubled breathing
- unexplained weight loss
- unsteadiness or awkwardness
- unusual tiredness or weakness
- weakness in the arms, hands, legs, or feet
- yellow eyes or skin
- Chest pain
- general feeling of discomfort or illness
- irregular heartbeat, recurrent
- thickening of bronchial secretions
Side effects not requiring immediate medical attention
Some side effects of ceritinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Blurred vision or other changes in vision
- difficulty having a bowel movement
- pain or discomfort in the chest, upper stomach, or throat
- seeing flashes or sparks of light
For Healthcare Professionals
Applies to ceritinib: oral capsule, oral tablet
The most common side effect resulting in dose reductions or interruptions were increased ALT (29%), nausea (20%), increased AST (16%), diarrhea (16%), and vomiting (16%).
Rare (less than 0.1%): GI hemorrhage[Ref]
Very Common (10% or more): Hemoglobin decreased (84%), phosphate decreased (36%)[Ref]
Very Common (10% or more): ALT increased (80%), AST increased (75%), bilirubin increased (15%)[Ref]
Very Common (10% or more): Creatinine increased (58%), phosphate decreased (36%)[Ref]
Very common (10% or more): Decreased appetite (34%), glucose increased (49%), lipase increased (28%)[Ref]
Very common (10% or more): Rash (16%)[Ref]
Common (1% to 10%): Interstitial lung disease/pneumonitis
Very common (10% or more): Neuropathy (17%)[Ref]
Common (1% to 10%): Vision disorder[Ref]
Common (1% to 10%): Prolonged QT, bradycardia
Rare (less than 0.1%): Cardiac tamponade[Ref]
Very common (10% or more): Fatigue (52%)
Uncommon (0.1% to 1%): General physical health deterioration[Ref]
1. "Product Information. Zykadia (ceritinib)." Novartis Pharmaceuticals, East Hanover, NJ.
More about Zykadia (ceritinib)
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: multikinase inhibitors
- FDA Approval History
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.