Zomig-ZMT Side Effects

Generic name: zolmitriptan

Medically reviewed by Drugs.com. Last updated on Jun 24, 2024.

Note: This document provides detailed information about Zomig-ZMT Side Effects associated with zolmitriptan. Some dosage forms listed on this page may not apply specifically to the brand name Zomig-ZMT.

Applies to zolmitriptan: nasal spray.

Other dosage forms:

• oral tablet, oral tablet disintegrating

Common side effects of Zomig-ZMT

Some side effects of zolmitriptan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• bad, unusual, or unpleasant (after) taste
• change in taste

Less common side effects

• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• discomfort, irritation, or soreness in the nose
• dry mouth
• increased sensitivity to pain
• increased sensitivity to touch
• lack or loss of strength
• sleepiness or unusual drowsiness

Less common or rare side effects

• continuing ringing or buzzing or other unexplained noise in the ears
• discouragement
• fear
• feeling sad or empty
• frequent urination
• hearing loss
• hyperventilation
• increased volume of pale, dilute urine
• irritability
• lack of appetite
• loss of interest or pleasure
• loss of memory
• problems with memory
• trouble concentrating
• trouble sleeping

Rare side effects

• burning, dry, or itching eyes
• convulsions
• discharge or excessive tearing
• redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
• swelling or inflammation of the mouth

Serious side effects of Zomig-ZMT

Along with its needed effects, zolmitriptan (the active ingredient contained in Zomig-ZMT) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zolmitriptan:

Less common or rare side effects

• blurred vision
• cough
• difficulty with swallowing
• dizziness
• fainting
• fast, slow, pounding, or irregular heartbeat or pulse
• headache
• nervousness
• pounding in the ears
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• shortness of breath
• skin rash, hives, or itching
• tightness in the chest
• unusual tiredness or weakness

Rare side effects

• arm, back, or jaw pain
• chest pain or discomfort
• chest tightness or heaviness
• nausea
• pain or discomfort in the arms, jaw, back, or neck
• sweating

Incidence not known

• agitation
• bloody diarrhea
• confusion
• diarrhea
• fever
• overactive reflexes
• pain, pressure, or tightness in the chest, throat, neck, or jaw
• paleness or cold feeling in the fingertips and toes
• poor coordination
• restlessness
• severe stomach pain
• shivering
• talking or acting with excitement you cannot control
• tingling or pain in the fingers or toes when exposed to cold
• trembling or shaking
• twitching

For healthcare professionals

Applies to zolmitriptan: nasal spray, oral tablet, oral tablet disintegrating.

General adverse events

The most common adverse reactions included neck, throat, jaw pain; dizziness; paresthesia; asthenia; somnolence; warm and cold sensation; nausea; heaviness sensation; and dry mouth. In adolescents treated with the nasal spray, the more commonly reported adverse reactions included dysgeusia, nasal discomfort, dizziness, oropharyngeal pain, and nausea.^[Ref]

Nervous system

• Very common (greater than 10%): Taste disturbances (up to 21%, inhaler)
• Common (1% to 10%): Paresthesia, somnolence, dizziness, hyperesthesia
• Rare (less than 0.1%): Cerebral ischemia, amnesia, convulsions, ataxia, dystonia, hyperkinesia, hypotonia, hypertonia
• Frequency not reported: Serotonin syndrome^[Ref]

Paresthesia appears to be a dose-related adverse event occurring in 5%, 7%, and 9% of patients receiving 1 mg, 2.5 mg, and 5 mg, respectively.^[Ref]

Other

• Common (1% to 10%): Warm/cold sensation, heaviness other than chest or neck, pressure/tightness/heaviness, vertigo, asthenia, chills
• Uncommon (0.1% to 1%): Tinnitus, hyperacusis, ear pain^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, dry mouth, dysphagia, dyspepsia, abdominal pain, vomiting
• Uncommon (0.1% to 1%): Gastroenteritis, increased thirst
• Rare (less than 0.1%): Stomatitis, constipation, hematemesis, pancreatitis, melena, ulcer
• Very rare (less than 0.01%): Bloody diarrhea, gastrointestinal infarction or necrosis, gastrointestinal ischemic events, ischemic colitis, splenic infarction^[Ref]

Cardiovascular

• Common (1% to 10%): Chest pain/tightness/pressure and/or heaviness, neck/throat/jaw pain/tightness/pressure, palpitations
• Uncommon (0.1% to 1%): Arrhythmias, hypertension, syncope, tachycardia
• Rare (less than 0.1%): Angina pectoris, myocardial infarct, coronary vasospasm, QT prolongation, thrombophlebitis^[Ref]

Rare reports of serious cardiac adverse events have been reported including acute myocardial infarction within a few hours following administration of this drug.

Chest pain/tightness/pressure and/or heaviness appear to be dose-related occurring in 2%, 3%, and 4% of patients receiving 1 mg, 2.5 mg, and 5 mg, respectively. Neck/throat/jaw pain/tightness/pressure occurred in 4%, 7%, and 10% of patients, respectively.^[Ref]

Hematologic

• Uncommon (0.1% to 1%): ecchymosis
• Rare (less than 0.1%): Thrombocytopenia, eosinophilia, leucopenia^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Increased appetite, thirst
• Rare (less than 0.1%): Anorexia, hyperglycemia^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, myalgia, muscle weakness
• Uncommon (0.1% to 1%): Back pain, leg cramps, tenosynovitis
• Rare (less than 0.1%): Arthritis, tetanus, twitching^[Ref]

Respiratory

• Common (1% to 10%): Disorder/discomfort of nasal cavity, throat pain, throat tightness, oropharyngeal pain
• Uncommon (0.1% to 1%): Pharyngitis, rhinitis, dyspnea, sinusitis, bronchitis, increased cough, epistaxis, laryngeal edema, hiccup, laryngitis, yawn
• Rare (less than 0.1%): Apnea, voice alteration^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Allergic reactions
• Postmarketing reports: Hypersensitivity reactions including angioedema, anaphylactic reactions and anaphylactic shock^[Ref]

Ocular

• Rare (less than 0.1%): Diplopia, dry eyes, lacrimation, conjunctivitis, eye pain, visual field defect^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Polyuria, urinary urgency, cystitis, hematuria
• Rare (less than 0.1%): Urinary frequency, miscarriage, dysmenorrhea^[Ref]

Dermatologic

• Common (1% to 10%): Sweating, facial edema
• Uncommon (0.1% to 1%): Urticaria, pruritus, rash, photosensitivity reaction
• Rare (less than 0.1%): Angioedema^[Ref]

Local

• Common (1% to 10%): Local irritation or soreness at the site of administration of nasal spray

In clinical trials using the nasal spray approximately 3% (n=460) patients reported local irritation or soreness at the site of administration. Effects were severe in about 1% of patients and approximately 57% resolved in 1 hour. Nasopharyngeal examinations of a subset of patients failed to demonstrate any clinically significant changes with repeated use of the nasal spray.

Frequently asked questions

• How long does Zomig take to work?

Further information

Zomig-ZMT side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer