Z-Clinz 5 Side Effects

Generic name: benzoyl peroxide / clindamycin topical

Medically reviewed by Drugs.com. Last updated on Oct 27, 2024.

Note: This document provides detailed information about Z-Clinz 5 Side Effects associated with benzoyl peroxide / clindamycin topical. Some dosage forms listed on this page may not apply specifically to the brand name Z-Clinz 5.

Applies to benzoyl peroxide/clindamycin topical: topical gel, topical kit.

Benzoyl peroxide can cause a rare but serious allergic reaction or severe skin irritation. These reactions may occur just a few minutes after you apply the medicine, or within a day or longer afterward.

Stop using this medicine and get emergency medical help if you have signs of an allergic reaction: hives, itching; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• severe redness, burning, stinging, or peeling of treated skin areas; or

• diarrhea that is watery or bloody.

Common side effects may include:

• mild burning or stinging;

• itching or tingly feeling;

• dryness or peeling of treated skin; or

• redness or other irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to benzoyl peroxide/clindamycin topical: topical gel, topical kit.

General adverse events

The most frequently reported side effects were erythema, scaling, peeling, dry skin, and itching.^[Ref]

Dermatologic

• Very common (10% or more): Erythema (up to 28%), scaling (up to 19%), peeling (up to 17%), dry skin (up to 15%), itching (up to 15%)
• Common (1% to 10%): Pruritus, sunburn, burning, stinging
• Uncommon (0.1% to 1%): Contact dermatitis, rash, acne worsened
• Postmarketing reports: Urticaria^[Ref]

Gastrointestinal

• Frequency not reported: Colitis
• Postmarketing reports: Pseudomembranous colitis, hemorrhagic diarrhea, diarrhea, abdominal pain^[Ref]

Immunologic

• Postmarketing reports: Anaphylaxis, allergic reaction^[Ref]

Local

• Common (1% to 10%): Application site reaction
• Uncommon (0.1% to 1%): Application site pain, application site exfoliation, application site irritation
• Postmarketing reports: Discoloration^[Ref]

Nervous system

• Common (1% to 10%): Headache
• Uncommon (0.1% to 1%): Paresthesia^[Ref]

See also:

Further information

Z-Clinz 5 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer