Vyvanse Side Effects

Generic Name: lisdexamfetamine

Note: This page contains side effects data for the generic drug lisdexamfetamine. It is possible that some of the dosage forms included below may not apply to the brand name Vyvanse.

In Summary

Common side effects of Vyvanse include: insomnia and irritability. Other side effects include: dizziness, weight loss, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lisdexamfetamine: oral capsule, oral tablet chewable

As well as its needed effects, lisdexamfetamine (the active ingredient contained in Vyvanse) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking lisdexamfetamine, check with your doctor immediately:

• Uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)

• Agitation
• blistering, peeling, or loosening of the skin
• chest discomfort or pain
• chills
• confusion
• cough
• diarrhea
• difficulty with breathing
• difficulty with swallowing
• discouragement
• dizziness
• faintness
• fast, irregular, pounding, or racing heartbeat or pulse
• feeling sad or empty
• fever
• hives or welts, itching, or skin rash
• irritability
• joint or muscle pain
• lack of appetite
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of interest or pleasure
• overreactive reflexes
• poor coordination
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red skin lesions, often with a purple center
• red, irritated eyes
• redness of the skin
• shivering
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• sweating
• swelling of the feet or lower legs
• talking or acting with excitement you cannot control
• tightness in the chest
• trembling or shaking
• trouble concentrating
• trouble sleeping
• twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
• unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking lisdexamfetamine, get emergency help immediately:

• Abdominal or stomach cramps
• blurred vision
• change in consciousness
• confusion
• dark-colored urine
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fast breathing
• loss of consciousness
• muscle cramps or spasms
• muscle pain or stiffness
• nervousness
• overactive reflexes
• panic states
• physical attempt to injure yourself
• pounding in the ears
• restlessness
• seeing, hearing, or feeling things that are not there
• seizures
• shakiness in the legs, arms, hands, or feet
• sweating
• trembling or shaking of the hands or feet
• violent actions

Minor Side Effects

Some lisdexamfetamine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

• Decreased appetite
• headache
• nausea
• upper abdominal or stomach pain
• vomiting
• weight decreased

• Crying
• depersonalization
• dry mouth
• dysphoria
• euphoria
• paranoia
• quick to react or overreact emotionally
• rapidly changing moods
• sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to lisdexamfetamine: oral capsule, oral tablet chewable

Other

Common (1% to 10%): Pyrexia, increased energy, fatigue^[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (36%), upper abdominal pain (12%)
Common (1% to 10%): Vomiting, nausea, diarrhea, constipation, gastroenteritis^[Ref]

Metabolic

Very common (10% or more): Decreased appetite (39%), decreased weight (16.3%)
Common (1% to 10%): Anorexia^[Ref]

Nervous system

Very common (10% or more): Headache (20.3%)
Common (1% to 10%): Dizziness, somnolence, tremor, paresthesia, nightmare, dyskinesia, seizures, psychomotor hyperactivity
Postmarketing reports: Dyskinesia^[Ref]

Psychiatric

Very common (10% or more): Insomnia (27%), irritability (10%)
Common (1% to 10%): Tic, anxiety, agitation, erectile dysfunction, decreased libido, affect lability, feeling jittery, restlessness, aggression, initial insomnia, bruxism
Uncommon (0.1% to 1%): Logorrhea, depression, dysphoria, euphoria, dermatillomania, mania, hallucinations
Postmarketing reports: Libido changes, frequent or prolonged erections, psychotic episodes^[Ref]

Dermatologic

Common (1% to 10%): Rash, hyperhidrosis, pruritus
Uncommon (0.1% to 1%): Urticaria
Postmarketing reports: Stevens-Johnson Syndrome, angioedema^[Ref]

Cardiovascular

Common (1% to 10%): Increased blood pressure, increased heart rate, tachycardia, palpitations
Uncommon (0.1% to 1%): Raynaud's phenomenon
Postmarketing reports: Cardiomyopathy^[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity
Postmarketing reports: Anaphylactic reaction^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection^[Ref]

Ocular

Uncommon (0.1% to 1%): Mydriasis, blurred vision
Postmarketing reports: Diplopia, visual accommodation difficulties^[Ref]

Hepatic

Postmarketing reports: Eosinophilic hepatitis^[Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis^[Ref]

Respiratory

Common (1% to 10%): Dyspnea, oropharyngeal pain^[Ref]

It is possible that some side effects of Vyvanse may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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