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Uprima Side Effects

Generic Name: apomorphine

Note: This document contains side effect information about apomorphine. Some of the dosage forms listed on this page may not apply to the brand name Uprima.

For the Consumer

Applies to apomorphine: subcutaneous solution

Along with its needed effects, apomorphine (the active ingredient contained in Uprima) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking apomorphine:

More Common

  • Chest pain, discomfort, or pressure
  • chills
  • cold sweats
  • confusion
  • dizziness, faintness, or light-headedness when getting up from lying or sitting position
  • falling asleep during activity
  • mood or mental changes
  • seeing, hearing, or feeling things that are not there
  • swelling
  • twitching, twisting, uncontrolled repetitive movements of tongue, lips, face, arms, or legs

Less Common

Rare

  • Irregular heartbeat
  • recurrent fainting

Some side effects of apomorphine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site
  • blurred vision
  • dizziness
  • drowsiness
  • runny nose
  • sleepiness
  • yawning

Rare

  • Painful or prolonged erection of the penis

For Healthcare Professionals

Applies to apomorphine: compounding powder, subcutaneous solution

Gastrointestinal

Gastrointestinal side effects have included severe nausea (31%) and vomiting (11%) at the recommended doses of apomorphine (the active ingredient contained in Uprima) [Ref]

In clinical trials conducted in the USA, patients were treated with trimethobenzamide for 3 days prior to initiation of treatment with apomorphine, and were directed to continue it for at least 6 weeks. The number of patients stopping apomorphine treatment due to nausea was 3% and due to vomiting was 2%.[Ref]

Cardiovascular

Cardiovascular side effects have included syncope (2%). QT and QTc prolongation have been reported in very rare cases. Apomorphine (the active ingredient contained in Uprima) may cause dose-related decreases in systolic and diastolic blood pressure. Severe orthostatic hypotension, hypotension and/or syncope that resulted in drug withdrawal have been reported in less than 1% of patients in clinical trials.[Ref]

Psychiatric

Psychiatric side effects have included hallucinations (14%), confusion, paranoid ideation, delusions, disorientation, aggressive behavior, agitation, and delirium. Slowing down of cognitive performance has been reported after apomorphine (the active ingredient contained in Uprima) use in a small number of patients with Parkinson's disease. The mechanism of action is not fully understood.[Ref]

Other

Other side effects have included falling asleep during activities of daily living. There have been reports in the literature of patients suddenly falling asleep without prior warning, soon after receiving apomorphine (the active ingredient contained in Uprima) subcutaneous injections.[Ref]

Local

Local side effects have included reactions at the injection site, such as bruising (16%), granuloma (4%), and pruritus (2%).[Ref]

Other

Drug abuse and dependence have been reported rarely by patients with Parkinson's disease. These cases are characterized by frequent dosing leading to hallucinations, dyskinesia, and abnormal behavior.[Ref]

Nervous system

Nervous system side effects have included symptoms resembling neuroleptic malignant syndrome associated with the rapid dose reduction, withdrawal of, or changes in antiparkinsonian therapy. Migraine attacks have been reported to occur following injection of apomorphine (the active ingredient contained in Uprima) in two postmenopausal women who had experienced migraines before menopause several years earlier.[Ref]

Genitourinary

Genitourinary side effects have included priapism in some patients.[Ref]

Other

Drug tolerance to apomorphine (the active ingredient contained in Uprima) after long periods of drug treatment has been observed in some studies. The decline in dopaminergic responsiveness was most noticeable with drug administrations set at 2-hour intervals.[Ref]

References

1. "Product Information. Apokyn (apomorphine)." Mylan Pharmaceuticals Inc, Morgantown, WV.

2. Ruzicka E, Roth J, Spackova N, Mecir P, Jech R "Apomorphine induced cognitive changes in Parkinson's disease." J Neurol Neurosurg Psychiatry 57 (1994): 998-1001

3. Sabatini U, Rascol O, Rascol A, Montastruc JL "Migraine attacks induced by subcutaneous apomorphine in two migrainous parkinsonian patients." Clin Neuropharmacol 13 (1990): 264-7

4. Gancher ST, Nutt JG, Woodward WR "Time course of tolerance to apomorphine in parkinsonism." Clin Pharmacol Ther 52 (1992): 504-10

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about Uprima (apomorphine)

Consumer resources

Other brands: Apokyn

Professional resources

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