Tylenol Allergy Multi-Symptom Nighttime Side Effects

Generic name: acetaminophen / diphenhydramine / phenylephrine

Medically reviewed by Drugs.com. Last updated on May 4, 2024.

Note: This document provides detailed information about Tylenol Allergy Multi-Symptom Nighttime Side Effects associated with acetaminophen / diphenhydramine / phenylephrine. Some dosage forms listed on this page may not apply specifically to the brand name Tylenol Allergy Multi-Symptom Nighttime.

Applies to acetaminophen / diphenhydramine / phenylephrine: oral liquid, oral powder for reconstitution, oral syrup, oral tablet.

Important warnings This medicine can cause some serious health issues

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days.

A dangerous drug interaction could occur.

MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Use this medicine exactly as directed.

An overdose of acetaminophen can damage your liver or cause death.

Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Do not use this medicine to make a child sleepy.

Some brands of acetaminophen, diphenhydramine, and phenylephrine are not approved for use in anyone younger than 12 years old.

Drinking alcohol may increase your risk of liver damage while taking acetaminophen.

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using this medicine and call your doctor at once if you have:

• severe drowsiness;

• painful or difficult urination;

• dizziness, trouble sleeping, nervousness; or

• liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

• drowsiness;

• dry eyes, blurred vision;

• dry mouth, nose, or throat;

• constipation; or

• feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to acetaminophen/diphenhydramine/phenylephrine: oral liquid, oral powder for reconstitution, oral syrup, oral tablet.

General adverse events

The manufacturer has not provided adverse event information.^[Ref]

Further information

Tylenol Allergy Multi-Symptom Nighttime side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer