Twinject Side Effects
Generic Name: epinephrine
Note: This page contains side effects data for the generic drug epinephrine. It is possible that some of the dosage forms included below may not apply to the brand name Twinject.
For the Consumer
Applies to epinephrine: injection injectable, injection solution
As well as its needed effects, epinephrine (the active ingredient contained in Twinject) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking epinephrine, check with your doctor immediately:Incidence not known:
- Abnormal or decreased touch sensation
- arm, back, or jaw pain
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- blurred vision
- chest pain or discomfort
- chest tightness or heaviness
- fast, irregular, pounding, or racing heartbeat or pulse
- fear or nervousness
- nausea or vomiting
- paleness of the skin
- pounding in the ears
- shakiness in the legs, arms, hands, or feet
- slow or fast heartbeat
- trembling or shaking of the hands or feet
- troubled breathing
- unusual tiredness or weakness
If any of the following symptoms of overdose occur while taking epinephrine, get emergency help immediately:Symptoms of overdose:
- coldness of the skin
- decreased urine output
- lightheadedness, dizziness, or fainting
- muscle twitching
- pounding, slow heartbeat
- rapid weight gain
- rapid, deep breathing
- stomach cramps
- swelling of the face, ankles, or hands
For Healthcare Professionals
Applies to epinephrine: compounding powder, inhalation aerosol, inhalation solution, injectable kit, injectable solution, intravenous solution, subcutaneous suspension
Due to the lack of randomized, controlled clinical trials for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of this drug is difficult to determine. The most commonly reported adverse reactions include anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and/or respiratory difficulties.[Ref]
Frequency not reported: Tachycardia, supraventricular tachycardia, ventricular arrhythmias, myocardial ischemia, myocardial infarction, limb/peripheral ischemia, palpitations, angina, arrhythmias, hypertension, vasoconstriction, ventricular ectopy, ventricular fibrillation, cold extremities, electrocardiogram changes, stress cardiomyopathy[Ref]
Frequency not reported: Headache, paresthesia, tremor, stroke, central nervous system bleeding, dizziness, cerebral hemorrhage, memory impaired, lightheadedness, psychomotor agitation, tingling, Parkinsonism aggravated, syncope, convulsions, subarachnoid hemorrhage, hemiplegia[Ref]
Frequency not reported: Nervousness, excitability, anxiety, apprehension, restlessness, disorientation, panic, hallucinations, psychosis, fear, sleeplessness/insomnia, tenseness, confusion, irritability[Ref]
Frequency not reported: Extravasation, injection site pallor, coldness at injection site, hypoesthesia at injection site, injury at injection site, local ischemic necrosis[Ref]
Frequency not reported: Diaphoresis, pallor, piloerection, skin blanching, skin necrosis with extravasation, necrotizing fasciitis, flushing/redness of skin and face, hyperhidrosis[Ref]
Frequency not reported: Hypoglycemia, hyperglycemia, insulin resistance, hypokalemia, lactic acidosis, insulin secretion inhibited, metabolic acidosis, anorexia[Ref]
Frequency not reported: Pulmonary edema, rales, respiratory difficulty, dyspnea, bronchospasm, hypoxia of mucosa[Ref]
Frequency not reported: Renal insufficiency[Ref]
Hypersensitivity side effects have been extremely unusual. Contact dermatitis has been associated with ocularly applied epinephrine (the active ingredient contained in Twinject) These reactions have typically presented with lid edema and a thick yellow discharge.
Frequency not reported: Nausea, vomiting, bowel necrosis, hypersalivation[Ref]
Frequency not reported: Urinary retention, difficult micturition[Ref]
Frequency not reported: Thrombocytosis[Ref]
Frequency not reported: Myonecrosis[Ref]
Frequency not reported: Chest pain, weakness, gas gangrene, asthenia[Ref]
Frequency not reported: Corneal endothelial damage[Ref]
Frequency not reported: Growth hormone secretion stimulated[Ref]
1. "Product Information. Epinephrine (EPINEPHrine)." Physicians Total Care, Tulsa, OK.
2. "Product Information. Auvi-Q (EPINEPHrine)." sanofi-aventis, Bridgewater, NJ.
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
4. "Product Information. EpiPen (EPINEPHrine)." Dey Laboratories, Napa, CA.
5. Cerner Multum, Inc. "Australian Product Information." O 0
6. "Product Information. Adrenalin (EPINEPHrine)." A-S Medication Solutions, Chicago, IL.
7. "Product Information. Adrenaclick Two-Pack (EPINEPHrine)." Amedra Pharmaceuticals LLC, Middlesex, NJ.
It is possible that some side effects of Twinject may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
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