Treprostinil Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 31, 2024.

For Healthcare Professionals

Applies to treprostinil: inhalation powder, inhalation solution, injectable solution, oral tablet extended release.

General

Oral tablets: The most frequently reported side effects were headache, diarrhea, nausea, and flushing.

Oral inhalation: The most frequently reported side effects were cough, headache, diarrhea, nausea, dizziness, throat irritation, pharyngolaryngeal pain, and flushing.

Parenteral: The most frequently reported side effects were subcutaneous infusion site pain and reaction, headache, diarrhea, nausea, jaw pain, vasodilation, edema, and hypotension.^[Ref]

Local

Very common (10% or more): Infusion site pain (up to 85%), infusion site reaction (up to 83%), Infusion site bleeding/bruising (33.5%)

Frequency not reported: Induration, erythema, infusion site infection

Postmarketing reports: Subcutaneous infusion site abscess^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 30%), nausea (up to 30%)

Common (1% to 10%): Abdominal discomfort, rectal hemorrhage, melena, vomiting, abdominal pain, dyspepsia

Frequency not reported: Gastrointestinal bleeding^[Ref]

Nervous system

Very common (10% or more): Headache (up to 63%)

Common (1% to 10%): Syncope, paresthesia, dizziness^[Ref]

Cardiovascular

Very common (10% or more): Flushing (15%), vasodilation (up to 11%)

Common (1% to 10%): Hypotension, tachycardia, palpitation, hypertension, heart failure, bradycardia, hemorrhage

Frequency not reported: Systemic blood pressure decreased, pallor, right ventricular heart failure, supraventricular tachycardia, hematoma

Postmarketing reports: Thrombophlebitis^[Ref]

Dermatologic

Very common (10% or more): Rash (up to 83.1%), pruritus (up to 13.6%)

Common (1% to 10%): Contact dermatitis, sweating, ecchymosis, cellulitis

Uncommon (0.1% to 1%): Skin ulcer

Postmarketing reports: Angioedema, macular rash, popular rash^[Ref]

Musculoskeletal

Very common (10% or more): Pain in extremity (14%), pain in jaw (up to 13.1%)

Common (1% to 10%): Myalgia, back pain

Uncommon (0.1% to 1%): Neck pain, arthralgia, leg cramp, muscle pain

Postmarketing reports: Bone pain, muscle spasm^[Ref]

Respiratory

Very common (10% or more): Cough (54%), throat irritation/pharyngolaryngeal pain (25%)

Common (1% to 10%): Hypoxia, epistaxis, pharyngitis, dyspnea, sinusitis, pulmonary hypertension, rhinitis, hemoptysis

Uncommon (0.1% to 1%): Bronchitis

Frequency not reported: Wheezing, pneumonia^[Ref]

Other

Very common (10% or more): Pain (11.9%)

Common (1% to 10%): Edema, infection, flu syndrome, asthenia, overdose, chest pain, fever, peripheral edema

Uncommon (0.1% to 1%): Viral infection, malaise

Frequency not reported: Infection, fatigue, BUN decreased, LDH decreased, bilirubin decreased, swelling arm^[Ref]

Metabolic

Common (1% to 10%): Hypokalemia, anorexia, dehydration, gout^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection^[Ref]

Hematologic

Common (1% to 10%): Anemia

Frequency not reported: Bleeding, thrombocytopenia, WBC decreased, RBC decreased, hemoglobin decreased, hematocrit decreased, eosinophils increased, platelet count increased^[Ref]