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Slynd Side Effects

Generic name: drospirenone

Medically reviewed by Last updated on Nov 21, 2020.

Note: This document contains side effect information about drospirenone. Some of the dosage forms listed on this page may not apply to the brand name Slynd.

For the Consumer

Applies to drospirenone: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, drospirenone (the active ingredient contained in Slynd) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking drospirenone:

Less common

Incidence not known

  • Absent, missed, or irregular menstrual periods
  • confusion
  • difficult breathing
  • irregular heartbeat
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • stomach pain
  • stopping of menstrual bleeding
  • vomiting
  • weakness or heaviness of the legs

Side effects not requiring immediate medical attention

Some side effects of drospirenone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Acne
  • breast pain or tenderness
  • cramps
  • decreased interest in sexual intercourse
  • headache
  • heavy bleeding
  • increased weight
  • loss in sexual ability, desire, drive, or performance
  • normal menstrual bleeding occurring earlier, possibly lasting longer than expected

For Healthcare Professionals

Applies to drospirenone: oral tablet


The most commonly reported adverse reactions have included acne, abnormal uterine bleeding, headache, breast pain, increased weight, dysmenorrhea, nausea, vaginal hemorrhage, decreased libido, breast tenderness, and irregular menstruation.[Ref]


Very common (10% or more): Unscheduled bleeding in cycle 1 (64.4%); unscheduled bleeding in cycle 13 (40.3%)

Common (1% to 10%): Metrorrhagia, dysmenorrhea, vaginal hemorrhage, irregular menstruation

Frequency not reported: Amenorrhea


Common (1% to 10%): Increased weight

Frequency not reported: Hyperkalemia


Common (1% to 10%): Breast pain, breast tenderness


Common (1% to 10%): Decreased libido

Nervous system

Common (1% to 10%): Headache


Common (1% to 10%): Acne


Common (1% to 10%): Nausea


1. "Product Information. Slynd (drospirenone)." Exeltis USA, Inc., Chatham, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.