Skip to Content

Septocaine Side Effects

Generic Name: articaine / epinephrine

Note: This document contains side effect information about articaine / epinephrine. Some of the dosage forms listed on this page may not apply to the brand name Septocaine.

For the Consumer

Applies to articaine / epinephrine: parenteral injection

Side effects include:

Pain, headache, facial edema, gingivitis, paresthesia, infection.

For Healthcare Professionals

Applies to articaine / epinephrine: injectable solution


Other side effects including pain (up to 13%), headache (up to 5%), positive blood aspiration into syringe (3.2%), swelling (2.7%), face edema (1%), infection (1%), neck pain, abdominal pain, ear pain, taste perversion, and accidental injury have been reported.[Ref]


Gastrointestinal side effects including nausea and emesis (1.6%), gingivitis (1%), constipation, diarrhea, dyspepsia, glossitis, gum hemorrhage, mouth ulceration, nausea, stomatitis, tongue edema, tooth disorder, and vomiting have been reported.[Ref]


Musculoskeletal side effects including trismus (1.6%), arthralgia, myalgia, back pain, and osteomyelitis have been reported.[Ref]


General side effects including sleepiness (1.1%), malaise, and asthenia have been reported.

Nervous system

Nervous system side effects including paresthesia (1%), numbness and tingling (1%), dizziness, dry mouth, facial paralysis, hyperesthesia, increased salivation, nervousness, neuropathy, paresthesia, somnolence, and exacerbation of Kearns-Sayre syndrome have been reported.

Persistent paresthesias of the lips, tongue, and oral tissues have been reported with use of articaine, with slow, incomplete, or no recovery. These events have been reported chiefly following nerve blocks in the mandible and have involved the trigeminal nerve and its branches.[Ref]


Cardiovascular side effects including palpitation (1.0%), hemorrhage, migraine, syncope, tachycardia, and elevated blood pressure have been reported.[Ref]


Respiratory side effects including pharyngitis, rhinitis, sinus pain, and sinus congestion have been reported.


Hematologic side effects including ecchymosis and lymphadenopathy have been reported.


Metabolic side effects including edema and thirst have been reported.


Local side effects including injection site pain and a burning

sensation above the injection site have been reported.


Dermatologic side effects including pruritus and skin disorder have been reported.


Genitourinary side effects including dysmenorrhea have been reported.


1. "Product Information. Septocaine (articaine-epinephrine)." Septodont Incorporated, New Castle, DE.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.