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Santyl Side Effects

Generic name: collagenase topical

Medically reviewed by Drugs.com. Last updated on Jun 30, 2022.

Note: This document contains side effect information about collagenase topical. Some of the dosage forms listed on this page may not apply to the brand name Santyl.

For the Consumer

Applies to collagenase topical: topical application ointment

Side effects requiring immediate medical attention

Along with its needed effects, collagenase topical (the active ingredient contained in Santyl) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking collagenase topical:

Incidence not known

  • Chest tightness
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever
  • hives, itching, skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • trouble breathing

Side effects not requiring immediate medical attention

Some side effects of collagenase topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Redness around the wound area

For Healthcare Professionals

Applies to collagenase topical: compounding powder, topical ointment

General

The most commonly reported side effect was erythema.[Ref]

Hypersensitivity

Frequency not reported: Systemic manifestations of hypersensitivity (in a patient treated for more than one year with a combination of collagenase and cortisone)[Ref]

Dermatologic

Frequency not reported: Erythema[Ref]

References

1. "Product Information. Santyl (collagenase topical)." Knoll Pharmaceutical Company (2002):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.