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Rayaldee Side Effects

Generic Name: calcifediol

Note: This page contains side effects data for the generic drug calcifediol. It is possible that some of the dosage forms included below may not apply to the brand name Rayaldee.

In Summary

More frequent side effects include: increased serum calcium. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to calcifediol: oral capsule extended release, oral capsule liquid filled

As well as its needed effects, calcifediol (the active ingredient contained in Rayaldee) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking calcifediol, check with your doctor immediately:

Less common:
  • Abdominal or stomach pain
  • chest pain
  • confusion
  • cough
  • cough producing mucus
  • decreased urine output
  • difficulty with breathing
  • difficulty with moving
  • dilated neck veins
  • extreme fatigue
  • fever or chills
  • irregular breathing
  • irregular heartbeat
  • muscle pain or stiffness
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain, swelling, or redness in the joints
  • pale skin
  • sneezing
  • sore throat
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness or heaviness of the legs
  • weight gain
Incidence not known:
  • Confusion
  • constipation
  • depression
  • dry mouth
  • headache
  • incoherent speech
  • increased urination
  • loss of appetite
  • metallic taste
  • muscle weakness
  • thirst
  • weight loss

If any of the following symptoms of overdose occur while taking calcifediol, get emergency help immediately:

Symptoms of overdose:
  • Decreased appetite
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • high urine levels of calcium
  • increase in heart rate
  • irritability
  • lightheadedness
  • muscle weakness
  • rapid breathing
  • sunken eyes
  • wrinkled skin

Minor Side Effects

Some calcifediol side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

  • Bruise
  • muscle aches
  • stuffy or runny nose

For Healthcare Professionals

Applies to calcifediol: oral capsule, oral capsule extended release


Metabolic side effects have included hypercalcemia, and increased phosphate absorption.[Ref]

Early signs and symptoms of hypercalcemia include headache, anorexia, nausea, vomiting, metallic taste, constipation, abdominal cramps, dry mouth, weakness, fatigue, muscle and bone pain, ataxia, tinnitus, and vertigo. Later hypercalcemia may result in pruritus, mental confusion, coma, hypertension, cardiac arrhythmias, seizures, metastatic calcification, and renal insufficiency manifested by polyuria, nocturia, polydipsia, and proteinuria. Patients with renal failure are more prone to the development of hypercalcemia because the urinary excretion of calcium cannot compensate for increases in serum calcium.

Increased phosphate absorption may be detrimental in patients with chronic renal failure and hyperphosphatemia.

Because of the long half-life of calcifediol, reversal of toxic symptoms may take 7 to 30 days.[Ref]


1. "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.

2. "Calcifediol for renal osteodystrophy." Med Lett Drugs Ther 24 (1982): 92-3

3. Araugo OE, Flowers FP, Brown K "Vitamin D therapy in psoriasis." DICP 25 (1991): 835-9

4. Miller SM "New perspectives on vitamin D." Am J Med Technol 49 (1983): 27-37

It is possible that some side effects of Rayaldee may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.