Skip to Content

Calcifediol Pregnancy and Breastfeeding Warnings

Calcifediol is also known as: Calderol, Rayaldee

Calcifediol Pregnancy Warnings

Calcifediol has been assigned to pregnancy category C. Calcifediol has been shown to be teratogenic, resulting in external and skeletal abnormalities, when used at doses of 6 to 12 times the dose recommended for human use. There are no controlled data in human pregnancy. Calcifediol should only be used during pregnancy when benefit outweighs the risk.

Earlier literature expressed concerns over the development of supravalvular aortic stenosis, craniofacial abnormalities, and dental abnormalities in infants and children with idiopathic hypercalcemia. Whether or not prenatal factors predisposed these children to the development of hypercalcemia is not known. Fifteen hypoparathyroid women receiving 50,000 to 250,000 Intl units of vitamin D2 experienced 27 uneventful births. No cardiovascular or craniofacial abnormalities were reported.

See references

Calcifediol Breastfeeding Warnings

There are no data on the excretion of calcifediol into human milk.

See references

References for pregnancy information

  1. Rowe RD, Cooke RE "Vitamin D and craniofacial and dental anomalies of supravalvular stenosis." Pediatrics 43 (1969): 1-2
  2. Goodenday LS, Gordon GS "No risk from vitamin D in pregnancy." Ann Intern Med 75 (1971): 807-8
  3. Taussig HB "Possible injury to the cardiovascular system from vitamin D." Ann Intern Med 65 (1966): 1195-200
  4. "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.

References for breastfeeding information

  1. "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide