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Pyrukynd Side Effects

Generic name: mitapivat

Medically reviewed by Drugs.com. Last updated on Mar 15, 2025.

Note: This document provides detailed information about Pyrukynd.

Applies to mitapivat: oral tablet Side Effects associated with mitapivat. Some dosage forms listed on this page may not apply specifically to the brand name Pyrukynd.

Applies to mitapivat: oral tablet.

Precautions

It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests will be needed to check for unwanted effects.

Do not suddenly Stop taking mitapivat (the active ingredient contained in Pyrukynd) without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the risk of acute hemolysis (rapid breakdown of red blood cells). Call your doctor right away if you have confusion, dark urine, dizziness, trouble breathing, unusual tiredness or weakness, or yellow eyes or skin.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Pyrukynd

Along with its needed effects, mitapivat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mitapivat:

More common side effects

Incidence not known

  • back pain
  • chills
  • clay-colored stools
  • confusion
  • dark urine
  • decreased urination
  • fever
  • itching, rash
  • loss of appetite
  • nausea
  • pale skin
  • stomach pain
  • trouble breathing
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Other side effects of Pyrukynd

Some side effects of mitapivat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • breast discomfort
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • constipation
  • dry mouth
  • difficulty in moving
  • feeling of warmth
  • muscle pain or stiffness
  • pain in the joints
  • pain in the lower back, bottom, hips, or upper legs
  • redness of the face, neck, arms and occasionally, upper chest
  • sore throat

For healthcare professionals

Applies to mitapivat: oral tablet.

Endocrine adverse events

In 1 study, increases in serum testosterone and decreases in serum estrone and estradiol were observed in men receiving this drug; these hormone changes persisted throughout the study. Reproductive hormone analyses showed decreases in estrone and estradiol to below the lower limit of the reference range and increases in testosterone to above the upper limit of the reference range where baseline was within normal limits. In patients who discontinued this drug and had follow-up hormone measurements, the hormone changes returned close to the baseline levels 28 days after stopping this drug. In female patients, sex hormone analysis was limited due to physiologic variations in hormones during the menstrual cycle and the use of hormonal contraceptives.[Ref]

Musculoskeletal

Metabolic

Gastrointestinal

Cardiovascular

Respiratory

Other

Nervous system

Hematologic

Acute hemolysis with subsequent anemia was observed after abrupt interruption or discontinuation of this drug in dose-ranging study.[Ref]

See also:

References

1. (2022) "Product Information. Pyrukynd (mitapivat)." Agios Pharmaceuticals, Inc.

Further information

Pyrukynd side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.