Pyrukynd Side Effects

Generic name: mitapivat

Medically reviewed by Drugs.com. Last updated on Apr 7, 2023.

Note: This document contains side effect information about mitapivat. Some dosage forms listed on this page may not apply to the brand name Pyrukynd.

Applies to mitapivat: oral tablet.

Serious side effects of Pyrukynd

Along with its needed effects, mitapivat (the active ingredient contained in Pyrukynd) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mitapivat:

More common

Blurred vision
dizziness
headache
nervousness
pounding in the ears
slow or fast heartbeat

Incidence not known

Back pain
chills
clay-colored stools
confusion
dark urine
decreased urination
fever
itching, rash
loss of appetite
nausea
pale skin
stomach pain
trouble breathing
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
vomiting of blood
yellow eyes or skin

Other side effects of Pyrukynd

Some side effects of mitapivat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Breast discomfort
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
constipation
dry mouth
difficulty in moving
feeling of warmth
muscle pain or stiffness
pain in the joints
pain in the lower back, bottom, hips, or upper legs
redness of the face, neck, arms and occasionally, upper chest
sore throat

For Healthcare Professionals

Applies to mitapivat: oral tablet.

Endocrine

Very common (10% or more): Estrone decreased in males (56.3%), estradiol decreased in males (12.5%)

Common (1% to 10%): Blood testosterone increased in males^[Ref]

In 1 study, increases in serum testosterone and decreases in serum estrone and estradiol were observed in men receiving this drug; these hormone changes persisted throughout the study. Reproductive hormone analyses showed decreases in estrone and estradiol to below the lower limit of the reference range and increases in testosterone to above the upper limit of the reference range where baseline was within normal limits. In patients who discontinued this drug and had follow-up hormone measurements, the hormone changes returned close to the baseline levels 28 days after stopping this drug. In female patients, sex hormone analysis was limited due to physiologic variations in hormones during the menstrual cycle and the use of hormonal contraceptives.^[Ref]

Musculoskeletal

Very common (10% or more): Back pain (included back pain, sciatica, flank pain; 15%), arthralgia (included arthralgia, joint swelling; 10%)

Frequency not reported: Rib fracture, musculoskeletal pain^[Ref]

Metabolic

Very common (10% or more): Increased urate (15%)

Common (1% to 10%): Hypertriglyceridemia (included hypertriglyceridemia, blood triglycerides increased)^[Ref]

Gastrointestinal

Common (1% to 10%): Gastroenteritis, constipation, dry mouth (included dry mouth, dry lip)^[Ref]

Cardiovascular

Common (1% to 10%): Hot flush (included hot flush, flushing), hypertension, arrhythmia (included arrhythmia, tachycardia, heart rate increased, atrial fibrillation)

Frequency not reported: Atrial fibrillation^[Ref]