Promazine Side Effects
Applies to promazine: injectable solution, oral tablet
Involuntary rhythmical movements of the tongue, face and mouth characterize tardive dyskinesia. Early recognition of premonitory symptoms of tardive dyskinesia (like hyperkinetic dysarthria and fine vermiform movements of the tongue) may allow discontinuation of promazine before irreversible dyskinesia ensues.
Fever, altered consciousness, autonomic dysfunction and muscle rigidity are the hallmarks of the neuroleptic malignant syndrome. The neuroleptic malignant syndrome is associated with a case fatality rate of about 20%. Immediate discontinuation of neuroleptic therapy and intensive monitoring and supportive care are indicated.
Other side effects including tardive dyskinesia have been reported after administration of other phenothiazines and may be irreversible.
The neuroleptic malignant syndrome has been reported to occur in as many as 0.5 to 1% of patients taking other neuroleptic agents.
Withdrawal symptoms after abrupt discontinuation of promazine and other neuroleptics have been reported.
Sudden death after parenteral administration of other neuroleptics has been rarely reported in patients without underlying medical illness.[Ref]
Local side effects including intravenous and inadvertent intra-arterial injection of promazine have been associated with distal necrosis requiring amputation of the affected limb.[Ref]
Some investigators have suggested that endometrial sampling be performed in women taking neuroleptics if warranted by clinical suspicion.[Ref]
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Some side effects may not be reported. You may report them to the FDA.