Skip to Content

Prodrox Side Effects

Generic Name: hydroxyprogesterone

Note: This page contains side effects data for the generic drug hydroxyprogesterone. It is possible that some of the dosage forms included below may not apply to the brand name Prodrox.

For the Consumer

Applies to hydroxyprogesterone: intramuscular oil, intramuscular solution

As well as its needed effects, hydroxyprogesterone (the active ingredient contained in Prodrox) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking hydroxyprogesterone, check with your doctor or nurse immediately:

More common:
  • Pain, itching, or swelling at the injection site
Less common:
  • Small lumps at the injection site
Incidence not known:
  • Anxiety
  • chest pain
  • cough
  • dizziness or lightheadedness
  • fainting
  • fast heartbeat
  • redness, tenderness, or warmth on the skin
  • sudden shortness of breath or troubled breathing

Minor Side Effects

Some hydroxyprogesterone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Hives or welts
  • itching
  • nausea
  • skin rash
Less common:
  • Diarrhea

For Healthcare Professionals

Applies to hydroxyprogesterone: compounding powder, intramuscular solution


Genitourinary side effects have included admission for preterm labor, preeclampsia or gestational hypertension, gestational diabetes, and oligohydramnios. Postmarketing side effects include urinary tract infection, cervical incompetence, premature rupture of membranes, cervical dilation, and shortened cervix.[Ref]


Local side effects have included injection site pain, swelling, pruritus, and nodules. Postmarketing side effects include local injection site reactions of erythema, urticaria, rash, irritation, hypersensitivity, and warmth.[Ref]


Gastrointestinal side effects have included nausea and diarrhea. Postmarketing side effects include vomiting.[Ref]


Dermatologic side effects have included pruritus and urticaria. Postmarketing side effects include rash.[Ref]

Nervous system

Nervous system side effects include postmarketing reports of headache and dizziness.


Respiratory side effects include postmarketing reports of dyspnea and chest discomfort.


Other side effects include postmarketing reports of fatigue, fever, and hot flashes/flushes.


1. "Product Information. Makena (hydroxyprogesterone)." Ther-Rx Corporation, Bridgeton, MO.

It is possible that some side effects of Prodrox may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.