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Hydroxyprogesterone Dosage

Medically reviewed by Drugs.com. Last updated on Jun 22, 2023.

Applies to the following strengths: 250 mg/mL; 275 mg/1.1 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Premature Labor

Treatment should begin between 16 weeks, 0 days and 20 weeks, 6 days of gestation:

Intramuscularly (IM): 250 mg IM once every 7 day in the upper outer quadrant of the gluteus maximus

Subcutaneously: 275 mg subcutaneously once every 7 days in the back of either upper arm

Duration: Continue administration once a week until week 37 (through 36 weeks, 6 days) of gestation or delivery, whichever occurs first

Comments:


Use: To reduce the risk of preterm birth in women with a singleton pregnancy who have a history of singleton spontaneous preterm birth.

Usual Pediatric Dose for Premature Labor

16 years or older:
Treatment should begin between 16 weeks, 0 days and 20 weeks, 6 days of gestation:

Intramuscularly (IM): 250 mg IM once every 7 day in the upper outer quadrant of the gluteus maximus

Subcutaneously: 275 mg subcutaneously once every 7 days in the back of either upper arm

Duration: Continue administration once a week until week 37 (through 36 weeks, 6 days) of gestation or delivery, whichever occurs first

Comments:


Use: To reduce the risk of preterm birth in women with a singleton pregnancy who have a history of singleton spontaneous preterm birth.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Contraindicated in active liver disease

Precautions

CONTRAINDICATIONS:


On October 5, 2020, the US FDA proposed this drug be withdrawn from the market because the required postmarket study failed to verify clinical benefit. This drug received accelerated approval in 2011 to reduce the risk of preterm birth in women who had previously had an unexplained preterm birth before 37 weeks. The postmarket study failed to show efficacy for improving the health of babies born to women with a history of unexplained preterm birth; additionally, it did not reduce the risk of preterm birth.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
For IM or subcutaneous administration once every 7 days by a healthcare provider

Subcutaneous Auto-injector:



Storage requirements:
Subcutaneous Auto-injector:
Single and Multiple-Dose Vials:

Preparation techniques: See manufacturer product information

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.