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Probenecid Side Effects

Medically reviewed by Last updated on Feb 8, 2024.

Applies to probenecid: oral tablet.

Serious side effects of Probenecid

Along with its needed effects, probenecid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking probenecid:


Check with your doctor as soon as possible if any of the following side effects occur while taking probenecid:

Less common


Other side effects of Probenecid

Some side effects of probenecid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to probenecid: oral tablet.


In therapeutic doses, probenecid is generally well tolerated and has a low incidence of side effects.[Ref]


Frequency not reported: Anaphylaxis, Stevens-Johnson syndrome, urticaria, pruritus[Ref]


Frequency not provided: Precipitation of acute gouty arthritis[Ref]


Frequency not reported: Uric acid stones with or without hematuria, costovertebral pain, urinary frequency[Ref]


Frequency not reported: Nephrotic syndrome, with or without renal failure[Ref]


Rarely (less than 0.1%): Aplastic anemia, leucopenia, thrombocytopenia

Frequency not reported: Anemia, hemolytic anemia (which could be related to genetic deficiency of glucose-6-phosphate-dehydrogenase (G6PD) in red blood cells)[Ref]

Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency may increase the risk of probenecid-induced hemolytic anemia in some patients. However, probenecid has also been implicated in at least two cases of immune-mediated hemolytic anemia. In both cases, serum antibodies reacted with red blood cells only in the presence of probenecid. In one patient, a generalized rash, fever, malaise, and anorexia were also present.[Ref]


Frequency not reported: Anorexia, nausea, vomiting, sore gums[Ref]


Rare (less than 0.1%): Hepatic necrosis[Ref]

Nervous system

Frequency not reported: Headache, dizziness[Ref]


Rare (less than 0.1%): Toxic epidermal necrolysis (in combination with colchicine)

Frequency not reported: Dermatitis, alopecia, flushing[Ref]


1. Gutman AB (1966) "Uricosuric drugs with special reference to probenecid and sulfinpyrazone." Adv Pharmacol, 4, p. 91-142

2. Kickler TS, Buck S, Ness P, et al. (1986) "Probenecid induced immune hemolytic anemia." J Rheumatol, 13, p. 208-9

3. Myers KW, Katial RK, Engler RJM (1998) "Probenecid hypersensitivity in AIDS: a case report." Ann Allergy Asthma Immunol, 80, p. 416-8

4. (2004) "Product Information. Probenecid (probenecid)." Marlex Pharmaceuticals

5. Cerner Multum, Inc. "Australian Product Information."

6. Scott JT, O'Brien PK (1968) "Probenecid, nephrotic syndrome, and renal failure." Ann Rheum Dis, 27, p. 249-52

7. Hertz P, Yager H, Richardson JA (1972) "Probenecid-induced nephrotic syndrome." Arch Pathol, 94, p. 241-3

8. Sosler SD, Behzad O, Garratty G, et al. (1985) "Immune hemolytic anemia associated with probenecid." Am J Clin Pathol, 84, p. 391-4

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.