ProAmatine Side Effects

Generic name: midodrine

Medically reviewed by Drugs.com. Last updated on Oct 28, 2024.

Note: This document provides detailed information about ProAmatine Side Effects associated with midodrine. Some dosage forms listed on this page may not apply specifically to the brand name ProAmatine.

Applies to midodrine: oral tablet.

Precautions

Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hayfever, or sinus problems, since they may tend to increase your blood pressure.

Serious side effects of ProAmatine

Along with its needed effects, midodrine (the active ingredient contained in ProAmatine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking midodrine:

Other side effects of ProAmatine

Some side effects of midodrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to midodrine: oral tablet.

General adverse events

The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.^[Ref]

Cardiovascular

• Common (1% to 10%): Supine hypertension, flushing
• Uncommon (0.1% to 1%): Reflex bradycardia
• Rare (less than 0.1%): Tachycardia, palpitations
• Frequency not reported: Vasodilation/flushing face^[Ref]

Nervous system

• Very common (10% or more): Paresthesia (18.3%)
• Common (1% to 10%): Headache
• Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence^[Ref]

Dermatologic

• Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)
• Common (1% to 10%): Rash
• Frequency not reported: Skin hyperesthesia, erythema multiforme, dry skin^[Ref]

Genitourinary

• Very common (10% or more): Dysuria (13.4%)
• Frequency not reported: Impaired urination^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, dyspepsia, stomatitis
• Frequency not reported: Dry mouth, canker sore, pyrosis, gastrointestinal distress, flatulence, abdominal pain, vomiting, diarrhea^[Ref]

Other

• Common (1% to 10%): Chills, pain
• Frequency not reported: Asthenia^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Sleep disorders, insomnia, restlessness, excitability, irritability
• Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety^[Ref]

Hepatic

• Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes^[Ref]

Musculoskeletal

• Frequency not reported: Backache, leg cramps^[Ref]

Ocular

• Frequency not reported: Visual field defect^[Ref]

See also:

Further information

ProAmatine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer