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ProAmatine Side Effects

Generic Name: midodrine

Note: This page contains side effects data for the generic drug midodrine. It is possible that some of the dosage forms included below may not apply to the brand name ProAmatine.

For the Consumer

Applies to midodrine: oral tablet

As well as its needed effects, midodrine (the active ingredient contained in ProAmatine) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking midodrine, check with your doctor immediately:

More common:
  • Blurred vision
  • cardiac awareness
  • headache
  • pounding in the ears
Rare
  • Fainting
  • increased dizziness
  • slow pulse

Minor Side Effects

Some midodrine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Burning, itching, or prickling of the scalp
  • chills
  • goosebumps
  • urinary frequency, retention, or urgency
Less common:
  • Anxiety or nervousness
  • confusion
  • dry mouth
  • flushing
  • headache or feeling of pressure in the head
  • skin rash
Rare
  • Backache
  • canker sores
  • dizziness
  • drowsiness
  • dry skin
  • leg cramps
  • pain or sensitivity of the skin to touch
  • stomach problems such as gas, heartburn, or nausea
  • trouble seeing
  • trouble with sleeping
  • weakness

For Healthcare Professionals

Applies to midodrine: oral tablet

General

The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.[Ref]

Cardiovascular

Common (1% to 10%): Supine hypertension, flushing
Uncommon (0.1% to 1%): Reflex bradycardia
Rare (less than 0.1%): Tachycardia, palpitations
Frequency not reported: Vasodilation/flushing face[Ref]

Nervous system

Very common (10% or more): Paresthesia (18.3%)
Common (1% to 10%): Headache
Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence[Ref]

Dermatologic

Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)
Common (1% to 10%): Rash
Frequency not reported: Skin hyperesthesia, erythema multiforme, dry skin[Ref]

Genitourinary

Very common (10% or more): Dysuria (13.4%)
Frequency not reported: Impaired urination[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, dyspepsia, stomatitis
Frequency not reported: Dry mouth, canker sore, pyrosis, gastrointestinal distress, flatulence, abdominal pain, vomiting, diarrhea[Ref]

Other

Common (1% to 10%): Chills, pain
Frequency not reported: Asthenia[Ref]

Psychiatric

Uncommon (0.1% to 1%): Sleep disorders, insomnia, restlessness, excitability, irritability
Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety[Ref]

Hepatic

Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes[Ref]

Musculoskeletal

Frequency not reported: Backache, leg cramps[Ref]

Ocular

Frequency not reported: Visual field defect[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation, Eatontown, NJ.

It is possible that some side effects of ProAmatine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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