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ProAmatine Side Effects

Generic Name: midodrine

Note: This document contains side effect information about midodrine. Some of the dosage forms listed on this page may not apply to the brand name ProAmatine.

For the Consumer

Applies to midodrine: oral tablet

Along with its needed effects, midodrine (the active ingredient contained in ProAmatine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking midodrine:

More Common

  • Blurred vision
  • cardiac awareness
  • headache
  • pounding in the ears

Rare

Some side effects of midodrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Burning, itching, or prickling of the scalp
  • chills
  • goosebumps
  • urinary frequency, retention, or urgency

Less Common

  • Anxiety or nervousness
  • confusion
  • dry mouth
  • flushing
  • headache or feeling of pressure in the head
  • skin rash

Rare

For Healthcare Professionals

Applies to midodrine: oral tablet

General

The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.[Ref]

Cardiovascular

Common (1% to 10%): Supine hypertension, flushing

Uncommon (0.1% to 1%): Reflex bradycardia

Rare (less than 0.1%): Tachycardia, palpitations

Frequency not reported: Vasodilation/flushing face[Ref]

Nervous system

Very common (10% or more): Paresthesia (18.3%)

Common (1% to 10%): Headache

Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence[Ref]

Dermatologic

Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)

Common (1% to 10%): Rash

Frequency not reported: Skin hyperesthesia, erythema multiforme, dry skin[Ref]

Genitourinary

Very common (10% or more): Dysuria (13.4%)

Frequency not reported: Impaired urination[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, dyspepsia, stomatitis

Frequency not reported: Dry mouth, canker sore, pyrosis, gastrointestinal distress, flatulence, abdominal pain, vomiting, diarrhea[Ref]

Other

Common (1% to 10%): Chills, pain

Frequency not reported: Asthenia[Ref]

Psychiatric

Uncommon (0.1% to 1%): Sleep disorders, insomnia, restlessness, excitability, irritability

Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety[Ref]

Hepatic

Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes[Ref]

Musculoskeletal

Frequency not reported: Backache, leg cramps[Ref]

Ocular

Frequency not reported: Visual field defect[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation, Eatontown, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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