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ProAmatine Side Effects

Generic name: midodrine

Medically reviewed by Last updated on Oct 26, 2022.

Note: This document contains side effect information about midodrine. Some dosage forms listed on this page may not apply to the brand name ProAmatine.

Applies to midodrine: oral tablets.


  • Possible marked supine hypertension; use recommended only in patients whose lives are considerably impaired despite standard care.22 Clinical benefits of therapy likely correspond with increases in 1-minute SBP (surrogate marker of therapeutic efficacy).22 However, clinical benefits of midodrine therapy (e.g., improved ability to carry out activities of daily living) not established.22 (See Orthostatic Hypotension under Uses.)

Side effects include:

Supine and sitting hypertension, paresthesias and pruritus (mainly of the scalp), goosebumps, chills, urinary urge, urinary retention, urinary frequency.

For Healthcare Professionals

Applies to midodrine: oral tablet.


The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.[Ref]


Common (1% to 10%): Supine hypertension, flushing

Uncommon (0.1% to 1%): Reflex bradycardia

Rare (less than 0.1%): Tachycardia, palpitations

Frequency not reported: Vasodilation/flushing face[Ref]

Nervous system

Very common (10% or more): Paresthesia (18.3%)

Common (1% to 10%): Headache

Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence[Ref]


Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)

Common (1% to 10%): Rash

Frequency not reported: Skin hyperesthesia, erythema multiforme, dry skin[Ref]


Very common (10% or more): Dysuria (13.4%)

Frequency not reported: Impaired urination[Ref]


Common (1% to 10%): Nausea, dyspepsia, stomatitis

Frequency not reported: Dry mouth, canker sore, pyrosis, gastrointestinal distress, flatulence, abdominal pain, vomiting, diarrhea[Ref]


Common (1% to 10%): Chills, pain

Frequency not reported: Asthenia[Ref]


Uncommon (0.1% to 1%): Sleep disorders, insomnia, restlessness, excitability, irritability

Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety[Ref]


Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes[Ref]


Frequency not reported: Backache, leg cramps[Ref]


Frequency not reported: Visual field defect[Ref]


1. "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation (2001):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.