ProAmatine Side Effects
Generic name: midodrine
Medically reviewed by Drugs.com. Last updated on Oct 26, 2022.
Note: This document contains side effect information about midodrine. Some dosage forms listed on this page may not apply to the brand name ProAmatine.
Applies to midodrine: oral tablets.
- Possible marked supine hypertension; use recommended only in patients whose lives are considerably impaired despite standard care.22 Clinical benefits of therapy likely correspond with increases in 1-minute SBP (surrogate marker of therapeutic efficacy).22 However, clinical benefits of midodrine therapy (e.g., improved ability to carry out activities of daily living) not established.22 (See Orthostatic Hypotension under Uses.)
Side effects include:
Supine and sitting hypertension, paresthesias and pruritus (mainly of the scalp), goosebumps, chills, urinary urge, urinary retention, urinary frequency.
For Healthcare Professionals
Applies to midodrine: oral tablet.
The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.[Ref]
Common (1% to 10%): Supine hypertension, flushing
Uncommon (0.1% to 1%): Reflex bradycardia
Rare (less than 0.1%): Tachycardia, palpitations
Frequency not reported: Vasodilation/flushing face[Ref]
Very common (10% or more): Paresthesia (18.3%)
Common (1% to 10%): Headache
Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence[Ref]
Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)
Common (1% to 10%): Rash
Frequency not reported: Skin hyperesthesia, erythema multiforme, dry skin[Ref]
Very common (10% or more): Dysuria (13.4%)
Frequency not reported: Impaired urination[Ref]
Common (1% to 10%): Nausea, dyspepsia, stomatitis
Frequency not reported: Dry mouth, canker sore, pyrosis, gastrointestinal distress, flatulence, abdominal pain, vomiting, diarrhea[Ref]
Common (1% to 10%): Chills, pain
Frequency not reported: Asthenia[Ref]
Uncommon (0.1% to 1%): Sleep disorders, insomnia, restlessness, excitability, irritability
Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety[Ref]
Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes[Ref]
Frequency not reported: Backache, leg cramps[Ref]
Frequency not reported: Visual field defect[Ref]
More about ProAmatine (midodrine)
- Check interactions
- Reviews (8)
- Drug images
- Dosage information
- During pregnancy
- Drug class: miscellaneous cardiovascular agents
Related treatment guides
1. "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation (2001):
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.