Pipracil Side Effects
Generic name: piperacillin
Medically reviewed by Drugs.com. Last updated on Aug 9, 2022.
Note: This document contains side effect information about piperacillin. Some dosage forms listed on this page may not apply to the brand name Pipracil.
Applies to piperacillin: injectable powder for injection.
This drug was generally well tolerated. Local side effects (after IV or IM injection) were most common.[Ref]
Common (1% to 10%): Diarrhea, loose stools
Common (1% to 10%): Rash, pruritus
Frequency not reported: Vesicular eruptions/vesiculation, erythema multiforme, urticaria, toxic epidermal necrolysis, Stevens-Johnson syndrome, drug reactions with eosinophilia and systemic symptoms (DRESS), petechial rash/purpura, exanthematous pustulosis, bullous dermatosis, erythema nodosum, exanthems, exfoliative dermatitis, Jarisch-Herxheimer reaction[Ref]
An increased incidence of rash has been reported in cystic fibrosis patients.
DRESS has been reported, particularly with piperacillin-tazobactam.
Common (1% to 10%): Thrombophlebitis, injection site pain, injection site induration, injection site erythema
Thrombophlebitis was more likely when insufficiently diluted solution was injected into the vein.[Ref]
Common (1% to 10%): Drug fever
An increased incidence of fever has been reported in cystic fibrosis patients.
Frequency not reported: Anaphylactic/anaphylactoid reactions (some leading to shock and fatalities)[Ref]
Frequency not reported: Agranulocytosis, hemolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia, eosinophilia, bleeding disorders, positive Coombs tests, hemorrhage/bleeding, decreased prothrombin time, platelet dysfunction, prolonged bleeding times[Ref]
Risk factors for reversible leukopenia (neutropenia) included prolonged therapy with high doses or concomitant drugs that cause this effect.[Ref]
Neuromuscular excitability and convulsions have been reported when higher than recommended doses were given IV.[Ref]
Frequency not reported: Elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure[Ref]
Frequency not reported: Epistaxis
More about Pipracil (piperacillin)
- Check interactions
- Dosage information
- During pregnancy
- Drug class: antipseudomonal penicillins
Related treatment guides
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Some side effects may not be reported. You may report them to the FDA.