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Piperacillin use while Breastfeeding

Drugs containing Piperacillin: Zosyn, Pipracil

Piperacillin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Piperacillin is acceptable to use during breastfeeding. Limited information indicates that maternal doses of piperacillin up to 12 grams daily produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with penicillins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels. Piperacillin in a dosage of 4 g intravenously every 8 hours for at least 3 days was given to 8 women. Milk levels were measured after 2 subsequent doses. After the first dose, milk levels ranged from 0.49 to 1.5 mg/L in the 3 hours after the dose. Afer the second dose, milk levels ranged from 1.1 to 1.9 mg/L in the 3 hours after the dose. Peak milk levels occurred 2 to 3 hours after the dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Baier R, Wolnik L, Puppel H et al. Piperacillin concentrations in milk and serum from lactating women. Proc ICAAC. 1982;203. Abstract 779.

Piperacillin Identification

Substance Name

Piperacillin

CAS Registry Number

61477-96-1

Drug Class

Antiinfective Agents

Antibacterial Agents

Penicillins

Administrative Information

LactMed Record Number

217

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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