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Patiromer Side Effects

Medically reviewed by Last updated on Mar 12, 2023.

Applies to patiromer: oral powder for suspension.

Serious side effects of Patiromer

Along with its needed effects, patiromer may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking patiromer:

More common

  • Drowsiness
  • loss of appetite
  • mood or mental changes
  • muscle spasms (tetany) or twitching
  • nausea
  • seizures
  • trembling
  • unusual tiredness or weakness
  • vomiting

Other side effects of Patiromer

Some side effects of patiromer may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement

Less common

  • Bloated or full feeling
  • diarrhea
  • excess air or gas in the stomach or bowels
  • passing gas
  • stomach discomfort

For Healthcare Professionals

Applies to patiromer: oral powder for reconstitution.


The more commonly reported adverse reactions have included constipation, hypomagnesemia, diarrhea, nausea, abdominal discomfort, and flatulence.


Gastrointestinal events were generally mild to moderate and did not appear to be dose related. They often resolved spontaneously or with treatment. During clinical studies, the most commonly reported adverse reactions leading to discontinuation included vomiting, diarrhea, constipation, and flatulence.[Ref]

Common (1% to 10%): Constipation, diarrhea, nausea, abdominal discomfort, flatulence

Frequency not reported: Vomiting[Ref]


Uncommon (0.1% to 1%): Mild to moderate hypersensitivity reactions including edema of the lips[Ref]


Common (1% to 10%): Hypomagnesemia, hypokalemia[Ref]


1. Product Information. Veltassa (patiromer). Relypsa, Inc. 2015.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.