Patiromer Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 12, 2025.

Applies to patiromer: oral powder for suspension.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may cause hypomagnesemia (low magnesium levels in the blood). Check with your doctor right away if you have drowsiness, loss of appetite, mood or mental changes, muscle spasms (tetany) or twitching, seizures, nausea or vomiting, trembling, or unusual tiredness or weakness.

Serious side effects of patiromer

Along with its needed effects, patiromer may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking patiromer:

Other side effects of patiromer

Some side effects of patiromer may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to patiromer: oral powder for reconstitution.

General adverse events

The more commonly reported adverse reactions have included constipation, hypomagnesemia, diarrhea, nausea, abdominal discomfort, and flatulence.

Gastrointestinal

• Common (1% to 10%): Constipation, diarrhea, nausea, abdominal discomfort, flatulence
• Frequency not reported: Vomiting^[Ref]

Gastrointestinal events were generally mild to moderate and did not appear to be dose related. They often resolved spontaneously or with treatment. During clinical studies, the most commonly reported adverse reactions leading to discontinuation included vomiting, diarrhea, constipation, and flatulence.^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Mild to moderate hypersensitivity reactions including edema of the lips^[Ref]

Metabolic

• Common (1% to 10%): Hypomagnesemia, hypokalemia^[Ref]

See also:

Further information

Patiromer side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer