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Patiromer Side Effects

For the Consumer

Applies to patiromer: oral powder for suspension

Along with its needed effects, patiromer may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking patiromer:

More common
  • Drowsiness
  • loss of appetite
  • mood or mental changes
  • muscle spasms (tetany) or twitching
  • nausea or vomiting
  • seizures
  • trembling
  • unusual tiredness or weakness

Some side effects of patiromer may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement (stool)
Less common
  • Abdominal or stomach discomfort
  • bloated or full feeling
  • diarrhea
  • excess air or gas in the stomach or intestines
  • passing gas

For Healthcare Professionals

Applies to patiromer: oral powder for reconstitution


Common (1% to 10%): Constipation, diarrhea, nausea, abdominal discomfort, flatulence
Uncommon (0.1% to 1%): Vomiting[Ref]


Uncommon (0.1% to 1%): Edema of the lips[Ref]


Common (1% to 10%): Hypomagnesemia, hypokalemia[Ref]


Common (1% to 10%): Approximately 4.7% of patients in clinical trials developed hypokalemia with a serum potassium value less than 3.5 mEq/L. Approximately 9% of patients in clinical trials developed hypomagnesemia with a serum magnesium value less than 1.4 mg/dL.[Ref]


1. "Product Information. Veltassa (patiromer)." Relypsa, Inc., Redwood City, CA.

Some side effects of patiromer may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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