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Generic name: patiromerPAT-i-ROE-mer ]
Drug class: Cation exchange resins

Medically reviewed by Last updated on Jul 7, 2022.

What is Veltassa?

Veltassa is a medicine that binds itself to potassium in your digestive tract. This helps prevent your body from absorbing too much potassium. Patiromer also helps your body get rid of excess potassium through your stools (bowel movements).

Veltassa is used to treat hyperkalemia (high levels of potassium in your blood).

Veltassa works differently from other medicines because it passes through your stomach and into your intestines without being absorbed into your blood stream.


Avoid use of Veltassa if you have severe constipation, bowel obstruction or impaction. Veltassa may be not work effectively and may worsen your condition.

Veltassa also binds to magnesium in your digestive tract which can lead to low levels of magnesium in the body.

Avoid taking other medicines by mouth within 3 hours before or 3 hours after you take patiromer.

Before taking this medicine

To make sure Veltassa is safe for you, tell your doctor if you have:

  • bowel obstruction;

  • severe constipation; or

  • bowel problems caused by recent surgery.

Because Veltassa is not absorbed into the blood stream, this medicine is not expected to be harmful during pregnancy or while nursing a baby. Tell your doctor if you are pregnant or breast-feeding.

Veltassa is not approved for use by anyone younger than 18 years old.

How should I take Veltassa?

Take Veltassa as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Veltassa is usually taken once daily with or without food.

Veltassa oral powder must be mixed with water before you take it. Prepare each dose immediately prior to administration. Measure 1/3 cup of water. Pour half of the water into a glass, then add Veltassa and stir. Add the remaining half of the water and stir thoroughly. The powder will not dissolve and the mixture will look cloudy. Add more water to the mixture as needed for desired consistency. Drink the mixture immediately. If powder remains in the glass after drinking, add more water, stir and drink immediately. Repeat as needed to ensure the entire dose is administered.

Do not mix Veltassa oral powder with hot liquid or hot food. Do not take the dry powder without mixing it with water.

While using patiromer, you may need frequent blood tests.

Veltassa may be only part of a treatment program that also includes a special diet. Follow your doctor's instructions very closely.

Store unmixed oral powder in the refrigerator. Do not open a medicine packet until you are ready to mix a dose.

You may also store Veltassa at room temperature, away from moisture and heat. The powder must be used within 3 months of being taken out of the refrigerator.

Dosing information

Usual Adult Dose of Veltassa for Hyperkalemia:

-Initial dose: 8.4 g orally once a day
-Maintenance dose: The dose should be adjusted based on the serum potassium level and the desired target range (up to the maximum dose of 25.2 g orally once a day). The dose can be up-titrated based on the serum potassium level at 1 week or longer intervals, in increments of 8.4 g.

-This medicine can be administered with or without food.
-This drug should not be heated (e.g., microwave) or added to heated foods or liquids.
-This drug is not intended to be taken in its dry form.
-This drug should be administered at least 3 hours before or 3 hours after other oral medications.
-Serum potassium levels should be monitored.

-Use: For the treatment of hyperkalemia
-Limitation of Use: This drug should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause low potassium (leg cramps, constipation, fluttering in your chest, thirst, urination, numbness or tingling, muscle weakness or limp feeling).

What to avoid

Avoid taking other medicines within 3 hours before or 3 hours after you take Veltassa. Patiromer can make it harder for your body to absorb other medicines you take by mouth. This could make the other medicines less effective.

Veltassa side effects

Get emergency medical help if you have signs of an allergic reaction to Veltassa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • back-and-forth movements of the eyes;

  • a seizure (convulsions);

  • muscle pain or weakness;

  • numbness; or

  • tiredness.

Common Veltassa side effects may include:

  • constipation, diarrhea;

  • stomach pain, nausea; or

  • gas.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Veltassa?

Other drugs may interact with patiromer, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Veltassa only for the indication prescribed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.