Paromycin Side Effects
Generic name: paromomycin
Medically reviewed by Drugs.com. Last updated on Oct 16, 2023.
Note: This document provides detailed information about Paromycin Side Effects associated with paromomycin. Some dosage forms listed on this page may not apply specifically to the brand name Paromycin.
Applies to paromomycin: oral capsule.
Common side effects of Paromycin
Some side effects of paromomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Serious side effects of Paromycin
Along with its needed effects, paromomycin (the active ingredient contained in Paromycin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
For healthcare professionals
Applies to paromomycin: oral capsule.
Gastrointestinal
- Frequency not reported: Nausea, abdominal cramps, diarrhea, gastrointestinal intolerance, vomiting, abdominal discomfort, pancreatitis, elevated serum amylase[Ref]
Nausea, abdominal cramps, and diarrhea have been reported with doses greater than 3 g/day.
A patient with AIDS developed pancreatitis after 5 days of therapy with this drug for cryptosporidiosis. Serum amylase declined progressively after this drug was discontinued but became elevated after reinstitution of therapy.[Ref]
Nervous system
Ototoxicity and sensorineural damage have been reported, usually in patients who also had hepatic disease.[Ref]
Hepatic
- Frequency not reported: Elevated AST, elevated ALT[Ref]
Transient elevated AST (greater than 3 times the upper limit of normal [3 x ULN]) and ALT (greater than 3 x ULN) were reported in patients receiving an IM formulation during a clinical study.[Ref]
Other
- Frequency not reported: Pyrexia[Ref]
Pyrexia was reported in patients receiving an IM formulation during a clinical study.[Ref]
Local
- Frequency not reported: Injection site pain, injection site swelling[Ref]
Injection site pain and swelling were reported in patients receiving an IM formulation during a clinical study.[Ref]
References
1. Sullam PM, Slutkin G, Gottlieb AB, Mills J (1986) "Paromomycin therapy of endemic amebiasis in homosexual men." Sex Transm Dis, 13, p. 151-5
2. (2001) "Product Information. Humatin (paromomycin)." Parke-Davis
3. Tan WW, Chapnick EK, Abter EIM, Haddad S, Zimbalist EH, Lutwick LI (1995) "Paromomycin-associated pancreatitis HIV-related cryptosporidiosis." Ann Pharmacother, 29, p. 22-4
4. Sundar S, Jha TK, Thakur CP, Sinha PK, Bhattacharya SK (2007) "Injectable paromomycin for Visceral leishmaniasis in India." N Engl J Med, 356, p. 2571-81
5. Melbourne: Therapeutic Guidelines Limited (2015) eTG complete [Online] http://online.tg.org.au/complete/desktop/tgc.htm
More about Paromycin (paromomycin)
- Check interactions
- Compare alternatives
- Drug images
- Dosage information
- During pregnancy
- Drug class: amebicides
- Breastfeeding
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
Further information
Paromycin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
