Paromycin Side Effects
Generic Name: paromomycin
Note: This document contains side effect information about paromomycin. Some of the dosage forms listed on this page may not apply to the brand name Paromycin.
For the Consumer
Applies to paromomycin: oral capsule
Along with its needed effects, paromomycin (the active ingredient contained in Paromycin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Some side effects of paromomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
For Healthcare Professionals
Applies to paromomycin: oral capsule
Gastrointestinal side effects of paromomycin (the active ingredient contained in Paromycin) have commonly included nausea, vomiting, diarrhea, and abdominal discomfort, especially with doses greater than 3 g per day. Malabsorption of xylose and sucrose has been reported. A case of pancreatitis in an AIDS patient has been attributed to paromomycin.[Ref]
A patient with AIDS developed pancreatitis after five days of therapy with paromomycin for cryptosporidiosis. Serum amylase declined progressively after paromomycin was discontinued, but became elevated after reinstitution of therapy.[Ref]
Nephrotoxicity is a consideration with the use of any aminoglycoside, however, paromomycin (the active ingredient contained in Paromycin) is poorly absorbed by the gastrointestinal tract. Accumulation of paromomycin may be problematic in patients with impaired renal function and patients treated with multiple or prolonged courses of therapy.[Ref]
Hepatic side effects have included transient elevated aspartate transaminase (greater than 3 times ULN) and alanine transaminase (greater than 3 times ULN) in patients receiving intramuscular paromomycin (the active ingredient contained in Paromycin) during a clinical study.[Ref]
Other side effects have included pyrexia in patients receiving intramuscular paromomycin (the active ingredient contained in Paromycin) during a clinical study.[Ref]
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2. "Product Information. Humatin (paromomycin)." Parke-Davis, Morris Plains, NJ.
3. Tan WW, Chapnick EK, Abter EIM, Haddad S, Zimbalist EH, Lutwick LI "Paromomycin-associated pancreatitis HIV-related cryptosporidiosis." Ann Pharmacother 29 (1995): 22-4
4. Sundar S, Jha TK, Thakur CP, Sinha PK, Bhattacharya SK "Injectable paromomycin for Visceral leishmaniasis in India." N Engl J Med 356 (2007): 2571-81
5. Sullam PM, Slutkin G, Gottlieb AB, Mills J "Paromomycin therapy of endemic amebiasis in homosexual men." Sex Transm Dis 13 (1986): 151-5
6. Boston Collaborative Drug Surveillance Program "Drug-induced deafness." JAMA 224 (1973): 515-6
7. Berk DP, Chalmers T "Deafness complicating antibiotic therapy of hepatic encephalopathy." Ann Intern Med 73 (1970): 393-6
8. Kunin CM "Nephrotoxicity of antibiotics." JAMA 202 (1967): 204-8
Some side effects of Paromycin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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- Drug class: amebicides
Other brands: Humatin
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