Paromomycin Dosage

Usual Adult Dose for Amebiasis

25 to 35 mg/kg/day orally in 3 divided doses with meals for 5 to 10 days. Should be used following a course of metronidazole for the treatment of mild to severe, symptomatic disease. Paromomycin is not effective in extraintestinal amebiasis.

Usual Adult Dose for Cryptosporidiosis

25 to 35 mg/kg/day orally in 2 to 4 divided doses with meals for 10 to 14 days (investigational). Has occasionally been used for up to 4 to 6 weeks or longer in AIDS patients.

Usual Adult Dose for Dientamoeba fragilis

25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (unlabeled use).

Usual Adult Dose for Giardiasis

25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (investigational). Paromomycin is an alternative for the treatment of giardiasis. Metronidazole is generally considered the drug of choice.

Usual Adult Dose for Hymenolepis nana (Dwarf Tapeworm)

45 mg/kg orally once a day for 5 to 7 days (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Diphyllobothrium latum (Fish Tapeworm)

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Dipylidium caninum (Dog Tapeworm)

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Taenia saginata (beef tapeworm)

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Taenia solium (pork tapeworm)

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Hepatic Coma

Adjunct therapy: 1 gram four times a day for 5 to 7 days

Usual Pediatric Dose for Amebiasis

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 5 to 10 days. Should be used following a course of metronidazole for the treatment of mild to severe, symptomatic disease. Paromomycin is not effective in extraintestinal amebiasis.

Usual Pediatric Dose for Cryptosporidiosis

25 to 35 mg/kg/day orally in 3 divided doses with meals for 10 to 14 days (investigational). Has occasionally been used for up to 4 to 6 weeks or longer in AIDS patients.

Usual Pediatric Dose for Dientamoeba fragilis

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (unlabeled use).

Usual Pediatric Dose for Giardiasis

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (investigational). Paromomycin is an alternative for the treatment of giardiasis. Metronidazole is generally considered the drug of choice.

Usual Pediatric Dose for Hymenolepis nana (Dwarf Tapeworm)

<18 years: 45 mg/kg orally once a day for 5-7 days (unlabeled use).

Usual Pediatric Dose for Diphyllobothrium latum (Fish Tapeworm)

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Dipylidium caninum (Dog Tapeworm)

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Taenia saginata (beef tapeworm)

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Taenia solium (pork tapeworm)

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Renal Dose Adjustments

Data not available. Paromomycin is not absorbed systemically.

Liver Dose Adjustments

No adjustment recommended. Paromomycin does not undergo significant systemic absorption.

Precautions

Prolonged use may increase risk of ototoxicity.

Dialysis

No adjustment recommended. Paromomycin does not undergo significant systemic absorption.