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Olaparib Side Effects

Medically reviewed by Last updated on Nov 26, 2023.

Applies to olaparib: oral tablet.

Serious side effects of Olaparib

Along with its needed effects, olaparib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olaparib:

More common

Incidence not known

Other side effects of Olaparib

Some side effects of olaparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to olaparib: oral capsule, oral tablet.


The most common adverse reactions reported in 10% or greater patients were nausea (60%), fatigue (55%), anemia (36%), vomiting (32%), diarrhea (24%), decreased appetite (22%), headache (16%), dysgeusia (15%), cough (15%), neutropenia (14%), dyspnea (14%), dizziness (12%), dyspepsia (12%), leukopenia (11%), and thrombocytopenia (10%).


Very common (10% or more): Hypertension (19%)

Common (1% to 10%): Venous thrombosis[Ref]


Very common (10% or more): Dermatitis/rash (up to 15%)

Rare (0.01% to 0.1%): Angioedema, erythema nodosum[Ref]


Very common (10% or more): Nausea (up to 77%), abdominal pain/discomfort (up to 45%), vomiting (up to 40%), diarrhea (up to 37%), dyspepsia (up to 20%), constipation (28%), stomatitis (up to 11%)[Ref]


Very common (10% or more): Urinary tract infection (13%)[Ref]


Very common (10% or more): Decreased hemoglobin (up to 98%), elevated mean corpuscular volume (up to 89%), decreased lymphocytes (up to 77%), anemia (up to 46%), decreased absolute neutrophil count (up to 51%), decreased platelets (up to 56%), neutropenia (27%), leukopenia (25%), thrombocytopenia (14%)[Ref]

The term neutropenia includes febrile neutropenia, granulocyte count decreased, granulocytopenia, neutropenia, neutropenic infection, neutropenic sepsis, and neutrophil count decreased.[Ref]


Uncommon (0.1% to 1%): Hypersensitivity


Very common (10% or more): Decreased appetite (up to 30%), hypomagnesemia (14%)[Ref]


Very common (10% or more): Arthralgia/ myalgia, back pain (up to 19%)[Ref]

Nervous system

Very common (10% or more): Headache (up to 26%), dysgeusia (up to 27%), dizziness (up to 20%)[Ref]


Uncommon (0.1% to 1%): Myelodysplastic syndrome/Acute Myeloid Leukemia[Ref]


Very common (10% or more): Fatigue/malaise/asthenia/lethargy (up to 67%)

Common (1% to 10%): Pyrexia[Ref]


Very common (10% or more): Increased creatinine (up to 30%)[Ref]


Very common (10% or more): Nasopharyngitis/pharyngitis/upper respiratory infection (up to 43%), cough (up to 15%), dyspnea (15%)

Common (1% to 10%): Pulmonary embolism

Uncommon (0.1% to 1%): Pneumonitis

Frequency not reported: Rhinitis[Ref]

Frequently asked questions


1. Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals. 2014.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.