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Olaparib Side Effects

In Summary

Commonly reported side effects of olaparib include: upper respiratory tract infection, anemia, decreased hemoglobin, increased mcv, increased serum creatinine, nasopharyngitis, nausea, pharyngitis, vomiting, cough, and dyspnea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to olaparib: oral capsule

As well as its needed effects, olaparib may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking olaparib, check with your doctor immediately:

More common:
  • Chest pain
  • chills
  • cough
  • ear congestion or pain
  • fever
  • head congestion
  • hoarseness or other voice changes
  • nasal congestion
  • pale skin
  • runny nose
  • sneezing
  • sore throat
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common:
  • Lower back or side pain
  • painful or difficult urination
  • sores, ulcers, or white spots on lips or in the mouth
  • swollen glands

Minor Side Effects

Some olaparib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Acid or sour stomach
  • back pain
  • belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • blurred vision
  • burning, numbness, tingling, or painful sensations
  • cracked, dry, or scaly skin
  • decreased appetite
  • diarrhea
  • difficulty with moving
  • dry mouth
  • fear or nervousness
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • heartburn
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • lack or loss of strength
  • loss of bladder control
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • stomach discomfort, upset, or pain
  • sweating
  • swelling or inflammation of the mouth
  • trouble sleeping
  • unexplained weight loss
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to olaparib: oral capsule

Oncologic

Uncommon (0.1% to 1%): Myelodysplastic syndrome/Acute Myeloid Leukemia[Ref]

Hematologic

Very common (10% or more): Decreased hemoglobin (up to 90%), elevated mean corpuscular volume (up to 85%), decreased lymphocytes (up to 56%), anemia (up to 34%), decreased absolute neutrophil count (up to 32%), decreased platelets (up to 30%)
Common (1% to 10%): Leukopenia[Ref]

Respiratory

Very common (10% or more): Nasopharyngitis/pharyngitis/upper respiratory infection (up to 43%), cough (up to 21%), dyspnea
Common (1% to 10%): Pulmonary embolism
Uncommon (0.1% to 1%): Pneumonitis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 75%), abdominal pain/discomfort (up to 47%), vomiting (up to 43%), diarrhea (up to 31%), dyspepsia (up to 25%), constipation
Common (1% to 10%): Stomatitis[Ref]

Other

Very common (10% or more): Fatigue/asthenia/lethargy (up to 68%), peripheral edema
Common (1% to 10%): Pyrexia[Ref]

Renal

Very common (10% or more): Increased creatinine (up to 30%)[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia/musculoskeletal pain (up to 32%), myalgia (up to 25%), back pain (up to 25%)[Ref]

Cardiovascular

Common (1% to 10%): Hypertension, hot flush, venous thrombosis[Ref]

Dermatologic

Very common (10% or more): Dermatitis/rash (up to 25%)
Common (1% to 10%): Dry skin, eczema, pruritus[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection
Common (1% to 10%): Dysuria, urinary incontinence, vulvovaginal disorder[Ref]

Metabolic

Very common (10% or more): Decreased appetite (up to 25%)
Common (1% to 10%): Hypomagnesemia, hyperglycemia[Ref]

Nervous system

Very common (10% or more): Headache (up to 25%), dysgeusia (up to 21%), dizziness
Common (1% to 10%): Peripheral neuropathy[Ref]

Psychiatric

Common (1% to 10%): Anxiety, depression, insomnia[Ref]

References

1. "Product Information. Lynparza (olaparib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

It is possible that some side effects of olaparib may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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