Ofloxacin ophthalmic Side Effects

For the Consumer

Applies to ofloxacin ophthalmic: ophthalmic solution

As well as its needed effects, ofloxacin ophthalmic may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking ofloxacin ophthalmic, check with your doctor immediately:

• Puffiness or swelling of eyes
• signs of an allergic reaction, such as hives, itching, rash, swelling of face or lips, tightness in chest, troubled breathing, or wheezing

Severity: Moderate

If any of the following side effects occur while taking ofloxacin ophthalmic, check with your doctor or nurse as soon as possible:

• Dizziness

Minor Side Effects

Some ofloxacin ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

• Burning of eye

• Blurred vision
• eye pain
• feeling of something in the eye
• increased sensitivity of eye to light
• redness, irritation, or itching of eye, eyelid, or inner lining of eyelid
• stinging, tearing, or dryness of eye

For Healthcare Professionals

Applies to ofloxacin ophthalmic: ophthalmic solution

Ocular

Burning/stinging, tearing, and eye pain were reported in up to 14%, up to 11%, and up to 5% of treated eyes, respectively.

Burning/stinging, tearing, photophobia, and foreign body sensation were reported more often in patients treated for corneal ulcer.^[Ref]

Common (1% to 10%): Eye irritation, ocular discomfort
Frequency not reported: Transient ocular burning/discomfort, keratitis, conjunctivitis, eye edema, periorbital edema, foreign body sensation in eyes, dry eyes, ocular hyperemia, eye pruritus, eyelid pruritus, burning/stinging, redness, itching, chemical conjunctivitis/keratitis, ocular/periocular/facial edema, eye pain, photophobia, tearing, blurred vision, dryness
Postmarketing reports: Hypersensitivity, increased lacrimation^[Ref]

Hypersensitivity

Very rare (less than 0.01%)/Postmarketing reports: Hypersensitivity (including angioedema, dyspnea, anaphylactic reaction/shock, oropharyngeal swelling, swollen tongue)

Systemic ofloxacin:
-Frequency not reported: Hypersensitivity (anaphylactic/anaphylactoid) reactions

Serious and occasionally fatal hypersensitivity (anaphylactic/anaphylactoid) reactions (some after first dose) have been reported with systemic ofloxacin.

Cardiovascular

Ventricular arrhythmia and torsades de pointes were reported mainly in patients with risk factors for QT prolongation.

Frequency not reported: Ventricular arrhythmia, torsades de pointes, prolonged ECG QT

Nervous system

Frequency not reported: Dizziness^[Ref]

Gastrointestinal

Frequency not reported: Nausea^[Ref]

Other

Frequency not reported: Facial edema

It is possible that some side effects of ofloxacin ophthalmic may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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