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Nubeqa Side Effects

Generic name: darolutamide

Medically reviewed by Last updated on Oct 23, 2023.

Note: This document contains side effect information about darolutamide. Some dosage forms listed on this page may not apply to the brand name Nubeqa.

Applies to darolutamide: oral tablet.

Serious side effects of Nubeqa

Along with its needed effects, darolutamide (the active ingredient contained in Nubeqa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking darolutamide:

More common

  • Black, tarry stools
  • bleeding gums
  • blood in the urine
  • bloody nose
  • blurred vision
  • coughing or spitting up blood
  • difficulty in breathing or swallowing
  • dizziness
  • frequent urination
  • headache
  • lower abdominal or stomach cramping
  • nausea and vomiting
  • nervousness
  • nosebleeds
  • painful urination
  • paralysis
  • pounding in the ears
  • prolonged bleeding from cuts
  • red or dark brown urine
  • red or black, tarry stools
  • slow, fast, or irregular heartbeat
  • vomiting of blood or material that looks like coffee grounds
  • unusual bleeding or bruising

Less common

  • Blood in the urine
  • chest pain or discomfort
  • pain in the shoulders, arms, jaw, or neck
  • painful or difficult urination
  • seizures
  • sweating
  • trouble breathing

Other side effects of Nubeqa

Some side effects of darolutamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • decreased appetite
  • increased weight
  • pain in the arms or legs
  • rash
  • unusual tiredness or weakness

Less common

  • Chest pain or tightness
  • cough
  • fever or chills
  • muscle or bone pain
  • sneezing
  • sore throat


For Healthcare Professionals

Applies to darolutamide: oral tablet.


Very common (10% or more): Neutrophil count decreased (20%), bilirubin increased (16%)[Ref]


Very common (10% or more): Pain in extremity[Ref]


Common (1% to 10%): Urinary retention, hematuria[Ref]


Very common (10% or more): AST increased (23%)[Ref]


Common (1% to 10%): Pneumonia

Uncommon (0.1% to 1%): Pulmonary embolism[Ref]


Very common (10% or more): Fatigue (16%)

Uncommon (0.1% to 1%): General physical health deterioration, death[Ref]


Uncommon (0.1% to 1%): Cardiac failure, cardiac arrest, hypertension[Ref]


Common (1% to 10%): Rash[Ref]


Uncommon (0.1% to 1%): Diarrhea, nausea[Ref]


1. Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc. 2019.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.