Notuss-PE Side Effects

Generic name: codeine / phenylephrine

Note: This document provides detailed information about Notuss-PE Side Effects associated with codeine / phenylephrine. Some dosage forms listed on this page may not apply specifically to the brand name Notuss-PE.

Applies to codeine/phenylephrine: oral liquid.

Important warnings This medicine can cause some serious health issues

Do not use this medicine if you have used an MAO inhibitor in the past 14 days.

A dangerous drug interaction could occur.

MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Codeine can slow or stop your breathing. Never use this medicine in larger amounts, or for longer than prescribed. Codeine may also be habit-forming. Never share this medicine with another person. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH.

Medicines that contain codeine should not be given to a child just after surgery to remove the tonsils or adenoids. Get emergency medical help if a child taking this medicine has breathing problems, blue lips, or severe drowsiness, or if you cannot wake the child up from sleep.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Get emergency medical help if a child taking this medicine has breathing problems, blue lips, or severe drowsiness, or if you cannot wake the child up from sleep.

Stop using codeine and phenylephrine and call your doctor at once if you have:

• severe dizziness or drowsiness;

• weak or shallow breathing;

• severe restlessness or nervousness;

• severe constipation;

• pounding heartbeats or fluttering in your chest;

• painful or difficult urination; or

• little or no urinating.

Common side effects may include:

• mild drowsiness;

• dryness of your eyes, nose, and mouth;

• blurred vision; or

• nausea, vomiting, diarrhea, constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to codeine / phenylephrine: oral liquid.

General adverse events

The more commonly reported adverse effects have included nausea, vomiting, and dizziness.^[Ref]

Respiratory

Codeine:

• Frequency not reported: Respiratory depression

Phenylephrine:

• Frequency not reported: Respiratory distress^[Ref]

Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.^[Ref]

Gastrointestinal

• Frequency not reported: Nausea, vomiting, constipation, biliary tract spasm, increased colonic motility, toxic dilation^[Ref]

Codeine

Patients with chronic ulcerative colitis may experience increased colonic motility, while patients with acute ulcerative colitis have experienced toxic dilation with codeine use.^[Ref]

Cardiovascular

• Frequency not reported: Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension, circulatory depression

Phenylephrine:

• Frequency not reported: Ischemia^[Ref]

Codeine

Dermatologic

Codeine:

• Frequency not reported: Rash^[Ref]

Hypersensitivity

• Frequency not reported: Pruritus, giant urticaria, angioneurotic edema, laryngeal edema^[Ref]

Codeine

Psychiatric

• Frequency not reported: Euphoria, dysphoria, transient hallucination, disorientation

Phenylephrine:

• Frequency not reported: Anxiety, nervousness^[Ref]

Codeine

Nervous system

• Frequency not reported: CNS depression, lightheadedness, dizziness, sedation, headache, convulsions, weakness

Phenylephrine:

• Frequency not reported: Restlessness, dizziness, tremor, weakness^[Ref]

Codeine

Genitourinary

• Frequency not reported: Oliguria, urinary retention, antidiuretic effect^[Ref]

Codeine

Ocular

• Frequency not reported: Visual disturbances^[Ref]

Codeine

Other

Phenylephrine:

• Frequency not reported: Pain^[Ref]

Further information

Notuss-PE side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer