Notuss-PE Side Effects
Generic Name: codeine / phenylephrine
Note: This document contains side effect information about codeine / phenylephrine. Some of the dosage forms listed on this page may not apply to the brand name Notuss-PE.
Applies to codeine / phenylephrine: oral liquid
General
The more commonly reported adverse effects have included nausea, vomiting, and dizziness.[Ref]
Respiratory
Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.[Ref]
Codeine:
Frequency not reported: Respiratory depression
Frequency not reported: Respiratory distress[Ref]
Gastrointestinal
Patients with chronic ulcerative colitis may experience increased colonic motility, while patients with acute ulcerative colitis have experienced toxic dilation with codeine use.[Ref]
Codeine
Frequency not reported: Nausea, vomiting, constipation, biliary tract spasm, increased colonic motility, toxic dilation[Ref]
Cardiovascular
Codeine
Frequency not reported: Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension, circulatory depression
Frequency not reported: Ischemia[Ref]
Dermatologic
Codeine:
Frequency not reported: Rash[Ref]
Hypersensitivity
Codeine
Frequency not reported: Pruritus, giant urticaria, angioneurotic edema, laryngeal edema[Ref]
Psychiatric
Codeine
Frequency not reported: Euphoria, dysphoria, transient hallucination, disorientation
Frequency not reported: Anxiety, nervousness[Ref]
Nervous system
Codeine
Frequency not reported: CNS depression, lightheadedness, dizziness, sedation, headache, convulsions, weakness
Frequency not reported: Restlessness, dizziness, tremor, weakness[Ref]
Genitourinary
Codeine
Frequency not reported: Oliguria, urinary retention, antidiuretic effect[Ref]
Ocular
Codeine
Frequency not reported: Visual disturbances[Ref]
Other
Phenylephrine:
Frequency not reported: Pain[Ref]
References
1. "Product Information. Ala-Hist AC (codeine-phenylephrine)." Poly Pharmaceuticals Inc, Quitman, MS.
2. "Product Information. Promethazine VC with Codeine (codeine / phenylephrine/promethazine)." Par Pharmaceutical Inc (formerly Qualitest Pharmaceuticals Inc), Huntsville, AL.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
