Notuss-PE Side Effects

Generic Name: codeine / phenylephrine

Note: This page contains side effects data for the generic drug codeine / phenylephrine. It is possible that some of the dosage forms included below may not apply to the brand name Notuss-PE.

For the Consumer

Applies to codeine / phenylephrine: liquid

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; stomach pain; trouble sleeping.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty urinating; fast, slow, or irregular heartbeat; hallucinations; loss of coordination; mental or mood changes; numbness or tingling of the skin; persistent loss of appetite; persistent trouble sleeping; ringing in the ears; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; shortness of breath; tremor; wheezing.

For Healthcare Professionals

Applies to codeine / phenylephrine: oral liquid

General

The more commonly reported adverse effects have included nausea, vomiting, and dizziness.^[Ref]

Respiratory

Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.^[Ref]

Codeine:
Frequency not reported: Respiratory depression

Phenylephrine:
Frequency not reported: Respiratory distress^[Ref]

Gastrointestinal

Patients with chronic ulcerative colitis may experience increased colonic motility, while patients with acute ulcerative colitis have experienced toxic dilation with codeine use.^[Ref]

Codeine
Frequency not reported: Nausea, vomiting, constipation, biliary tract spasm, increased colonic motility, toxic dilation^[Ref]

Cardiovascular

Codeine
Frequency not reported: Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension, circulatory depression

Phenylephrine:
Frequency not reported: Ischemia^[Ref]

Dermatologic

Codeine:
Frequency not reported: Rash^[Ref]

Hypersensitivity

Codeine
Frequency not reported: Pruritus, giant urticaria, angioneurotic edema, laryngeal edema^[Ref]

Psychiatric

Codeine
Frequency not reported: Euphoria, dysphoria, transient hallucination, disorientation

Phenylephrine:
Frequency not reported: Anxiety, nervousness^[Ref]

Nervous system

Codeine
Frequency not reported: CNS depression, lightheadedness, dizziness, sedation, headache, convulsions, weakness

Phenylephrine:
Frequency not reported: Restlessness, dizziness, tremor, weakness^[Ref]

Genitourinary

Codeine
Frequency not reported: Oliguria, urinary retention, antidiuretic effect^[Ref]

Ocular

Codeine
Frequency not reported: Visual disturbances^[Ref]

Other

Phenylephrine:
Frequency not reported: Pain^[Ref]

It is possible that some side effects of Notuss-PE may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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