Myocard-DX Side Effects
Generic name: dopamine
Medically reviewed by Drugs.com. Last updated on Jun 10, 2024.
Note: This document provides detailed information about Myocard-DX Side Effects associated with dopamine. Some dosage forms listed on this page may not apply specifically to the brand name Myocard-DX.
Applies to dopamine: parenteral injection concentrate for iv infusion, parenteral injection for iv infusion.
Important warnings
This medicine can cause some serious health issues
-
Extravasation Risk
- Phentolamine is the local antidote for peripheral ischemia resulting from extravasation of dopamine.115 116
- Phentolamine should be given as soon as possible after extravasation is noted.115 116
- Infiltrate the affected area (using a syringe with a fine hypodermic needle) liberally throughout as soon as possible with 10–15 mL of 0.9% sodium chloride injection containing 5–10 mg of phentolamine mesylate (an α-adrenergic blocking agent) to prevent sloughing and necrosis in ischemic areas.115 116
- In children, phentolamine mesylate doses of 0.1–0.2 mg/kg (maximum: 10 mg per dose) may be infiltrated.116
- Sympathetic blockade with phentolamine causes immediate and conspicuous local hyperemic changes if the area is infiltrated within 12 hours.115 116
Side effects include:
Dopamine (the active ingredient contained in Myocard-DX) may cause cardiac conduction abnormalities (e.g., ventricular arrhythmia, atrial fibrillation, widened QRS complex, ectopic heartbeats), tachycardia, angina, palpitation, bradycardia, vasoconstriction, hypotension, hypertension, dyspnea, nausea, vomiting, headache, anxiety, azotemia, piloerection, and gangrene of the extremities.
For healthcare professionals
Applies to dopamine: intravenous solution.
Cardiovascular adverse events
- Common (1% to 10%): Ectopic beats, tachycardia, anginal pain, palpitation, hypotension, vasoconstriction
- Uncommon (0.1% to 1%): Aberrant ventricular conduction/ventricular arrhythmia, bradycardia, widened QRS complex, hypertension
- Frequency not reported: Gangrene of the feet/extremities, peripheral cyanosis, fatal ventricular arrhythmias, atrial fibrillation, cardiac conduction abnormalities[Ref]
Gangrene of the feet occurred in patients with preexisting vascular disorders and/or at doses of at least 10 to 14 mcg/kg/min given for prolonged periods of time.
Ventricular arrhythmias occurred at very high doses.[Ref]
Gastrointestinal
- Common (1% to 10%): Nausea, vomiting[Ref]
Nervous system
- Common (1% to 10%): Headache[Ref]
Respiratory
- Common (1% to 10%): Dyspnea[Ref]
Dermatologic
- Very rare (less than 0.01%): Gangrene
- Frequency not reported: Piloerection[Ref]
Local
- Frequency not reported: Necrosis, tissue sloughing, local ischemia and vasoconstriction[Ref]
Necrosis and tissue sloughing may be caused by extravasation of this drug.[Ref]
Psychiatric
- Frequency not reported: Anxiety[Ref]
Renal
- Frequency not reported: Azotemia[Ref]
Ocular
- Frequency not reported: Mydriasis[Ref]
Metabolic
- Frequency not reported: Hypovolemia[Ref]
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References
1. (2002) "Product Information. Intropin (dopamine)." DuPont Pharmaceuticals
2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
3. Cerner Multum, Inc. "Australian Product Information."
Frequently asked questions
More about Myocard-DX (dopamine)
Professional resources
Related treatment guides
Further information
Myocard-DX side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.