Mycostatin Topical Side Effects

Generic Name: nystatin topical

Note: This page contains information about the side effects of nystatin topical. Some of the dosage forms included on this document may not apply to the brand name Mycostatin Topical.

For the Consumer

Applies to nystatin topical: vaginal cream, vaginal tablet

In addition to its needed effects, some unwanted effects may be caused by nystatin topical (the active ingredient contained in Mycostatin Topical). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking nystatin topical, check with your doctor or nurse as soon as possible:

• Vaginal burning or itching not present before use of this medicine

For Healthcare Professionals

Applies to nystatin topical: topical cream, topical kit, topical ointment, topical powder, vaginal tablet

Dermatologic

Dermatologic side effects associated with nystatin topical (the active ingredient contained in Mycostatin Topical) powder, cream, and ointment have included skin irritation, burning, itching, rash, eczema, and pain on application in less than 0.1% of patients.^[Ref]

Genitourinary

Genitourinary side effects associated with nystatin vaginal tablets have included vaginal irritation, burning, and itching. At least one case of severe vulvovaginitis has also been reported.^[Ref]

A 64-year-old female experienced severe vulvovaginitis while receiving intravaginal nystatin therapy for Candida glabrata infection. She was administered nystatin vaginal tablets, 100,000 units twice daily for 14 days. She returned immediately after having completed the course complaining of intense skin rash in the vulvar area accompanied by severe irritation, burning, and itching. Therapy with a hydrocortisone cream and intramuscular betamethasone dipropionate was initiated. A week later, she had marked improvement with clearing of the vulvovaginal erythema and edema.^[Ref]

Hypersensitivity

Hypersensitivity side effects associated with nystatin topical (the active ingredient contained in Mycostatin Topical) powder, cream, and ointment have included allergic reactions and allergic contact dermatitis in less than 0.1% of patients. Stevens-Johnson syndrome has also been reported.

Not all side effects for Mycostatin Topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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