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Motofen Side Effects

Generic Name: atropine / difenoxin

Medically reviewed by Last updated on Oct 2, 2020.

Note: This document contains side effect information about atropine / difenoxin. Some of the dosage forms listed on this page may not apply to the brand name Motofen.

For the Consumer

Applies to atropine/difenoxin: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, atropine/difenoxin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atropine / difenoxin:

Get emergency help immediately if any of the following symptoms of overdose occur while taking atropine / difenoxin:

  • Blurred vision (continuing) or changes in near vision
  • drowsiness (severe)
  • dryness of mouth, nose, and throat (severe)
  • fast heartbeat
  • shortness of breath or troubled breathing (severe)
  • unusual excitement, nervousness, restlessness, or irritability
  • unusual warmth, dryness, and flushing of skin

Side effects not requiring immediate medical attention

Some side effects of atropine / difenoxin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • Blurred vision
  • confusion
  • difficult urination
  • dizziness or lightheadedness
  • drowsiness
  • dryness of skin and mouth
  • fever
  • headache
  • trouble in sleeping
  • unusual tiredness or weakness

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

  • Increased sweating
  • muscle cramps
  • nausea or vomiting
  • shivering or trembling
  • stomach cramps

For Healthcare Professionals

Applies to atropine / difenoxin: oral tablet


Common (1% to 10%): Vomiting, dry mouth, epigastric distress

Uncommon (0.1% to 1%): Constipation[Ref]

Nervous system

Common (1% to 10%): Dizziness and light-headedness, drowsiness, headache

Uncommon (0.1% to 1%): Tiredness, nervousness, insomnia, confusion[Ref]


Frequency not reported: Burning eyes, blurred vision[Ref]


1. "Product Information. Motofen (atropine-difenoxin)." Sebela Pharmaceuticals, Roswell, GA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.