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Metaglip Side Effects

Generic Name: glipizide / metformin

Note: This page contains information about the side effects of glipizide / metformin. Some of the dosage forms included on this document may not apply to the brand name Metaglip.

For the Consumer

Applies to glipizide / metformin: oral tablet

In addition to its needed effects, some unwanted effects may be caused by glipizide / metformin. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking glipizide / metformin:

More common:
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool pale skin
  • cough
  • depression
  • dizziness
  • fast heartbeat
  • fever
  • headache
  • increased hunger
  • nausea
  • nervousness
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common:
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • pounding in the ears
  • slow heartbeat
Rare
  • Abdominal discomfort
  • decreased appetite
  • diarrhea
  • fainting spells
  • fast, shallow breathing
  • general feeling of discomfort
  • muscle pain or cramping
  • shortness of breath
  • sleepiness
Symptoms of overdose:

If any of the following symptoms of overdose occur while taking glipizide / metformin, get emergency help immediately:

  • Abdominal discomfort
  • anxiety
  • behavior change, similar to drunkenness
  • blurred vision
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • decreased appetite
  • diarrhea
  • difficulty in concentrating
  • drowsiness
  • excessive hunger
  • fast heartbeat
  • fast, shallow breathing
  • general feeling of discomfort
  • headache
  • muscle pain or cramping
  • nausea
  • nervousness
  • nightmares
  • restless sleep
  • seizures
  • shakiness
  • slurred speech
  • unusual sleepiness
  • unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with glipizide / metformin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Muscle or bone pain
  • stomach pain
  • vomiting

For Healthcare Professionals

Applies to glipizide / metformin: oral tablet

Metabolic

Metabolic side effects, including lactic acidosis, which is a potentially fatal metabolic complication of biguanide therapy, has been reported in patients receiving metformin. The incidence of lactic acidosis has been about 0.03 cases per 1,000 patient years with approximately 0.015 fatal cases per 1,000 patient-years. The risk of lactic acidosis is particularly high in patients with underlying renal insufficiency. Cases of lactic acidosis occurring in patients with normal renal function have been rarely reported. Concomitant cardiovascular or liver disease, sepsis, and hypoxia may also increase the risk of lactic acidosis.[Ref]

Glipizide-Metformin:
Very Common (10% or more): Hypoglycemia (up to 12.6%)

Glipizide:
Common (1% to 10%): Hypoglycemia

Metformin:
Rare (less than 0.1%): Lactic acidosis[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 18.4%)
Common (1% to 10%): Nausea/vomiting, abdominal pain[Ref]

Hematologic

Glipizide:
Frequency not reported: Hemolytic anemia
Postmarketing reports: Hemolytic anemia in patients not known to have G6PD deficiency

Metformin:
Common (1% to 10%): Subnormal vitamin B12 levels
Frequency not reported: Anemia[Ref]

Hepatic

Glipizide:
Rare (less than 0.1%): Cholestatic and hepatocellular hepatic injury accompanied by jaundice[Ref]

Respiratory

Very common (10% or more): Upper respiratory infection (up to 10.3%)[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Cardiovascular

Common (1% to 10%): Hypertension[Ref]

Nervous system

Very common (10% or more): Headache (up to 12.6%)
Common (1% to 10%): Dizziness[Ref]

Musculoskeletal

Common (1% to 10%):: Musculoskeletal pain.[Ref]

References

1. "Product Information. Metaglip (glipizide-metformin)." Bristol-Myers Squibb, Princeton, NJ.

Not all side effects for Metaglip may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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