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Metaglip Side Effects

Generic Name: glipizide / metformin

Note: This document contains side effect information about glipizide / metformin. Some of the dosage forms listed on this page may not apply to the brand name Metaglip.

For the Consumer

Applies to glipizide / metformin: oral tablet

Along with its needed effects, glipizide/metformin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glipizide / metformin:

More common Less common
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • pounding in the ears
  • slow heartbeat
  • Abdominal discomfort
  • decreased appetite
  • diarrhea
  • fainting spells
  • fast, shallow breathing
  • general feeling of discomfort
  • muscle pain or cramping
  • shortness of breath
  • sleepiness
Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur while taking glipizide / metformin:

  • Abdominal discomfort
  • anxiety
  • behavior change, similar to drunkenness
  • blurred vision
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • decreased appetite
  • diarrhea
  • difficulty in concentrating
  • drowsiness
  • excessive hunger
  • fast heartbeat
  • fast, shallow breathing
  • general feeling of discomfort
  • headache
  • muscle pain or cramping
  • nausea
  • nervousness
  • nightmares
  • restless sleep
  • seizures
  • shakiness
  • slurred speech
  • unusual sleepiness
  • unusual tiredness or weakness

Some side effects of glipizide / metformin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common
  • Muscle or bone pain
  • stomach pain
  • vomiting

For Healthcare Professionals

Applies to glipizide / metformin: oral tablet


Metabolic side effects, including lactic acidosis, which is a potentially fatal metabolic complication of biguanide therapy, has been reported in patients receiving metformin. The incidence of lactic acidosis has been about 0.03 cases per 1,000 patient years with approximately 0.015 fatal cases per 1,000 patient-years. The risk of lactic acidosis is particularly high in patients with underlying renal insufficiency. Cases of lactic acidosis occurring in patients with normal renal function have been rarely reported. Concomitant cardiovascular or liver disease, sepsis, and hypoxia may also increase the risk of lactic acidosis.[Ref]

Very Common (10% or more): Hypoglycemia (up to 12.6%)

Common (1% to 10%): Hypoglycemia

Rare (less than 0.1%): Lactic acidosis[Ref]


Very common (10% or more): Diarrhea (up to 18.4%)
Common (1% to 10%): Nausea/vomiting, abdominal pain[Ref]


Frequency not reported: Hemolytic anemia
Postmarketing reports: Hemolytic anemia in patients not known to have G6PD deficiency

Common (1% to 10%): Subnormal vitamin B12 levels
Frequency not reported: Anemia[Ref]


Rare (less than 0.1%): Cholestatic and hepatocellular hepatic injury accompanied by jaundice[Ref]


Very common (10% or more): Upper respiratory infection (up to 10.3%)[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Hypertension[Ref]

Nervous system

Very common (10% or more): Headache (up to 12.6%)
Common (1% to 10%): Dizziness[Ref]


Common (1% to 10%):: Musculoskeletal pain.[Ref]


1. "Product Information. Metaglip (glipizide-metformin)." Bristol-Myers Squibb, Princeton, NJ.

Some side effects of Metaglip may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.