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Marqibo Side Effects

Generic name: vincristine liposome

Medically reviewed by Last updated on May 6, 2022.

Note: This document contains side effect information about vincristine liposome. Some of the dosage forms listed on this page may not apply to the brand name Marqibo.


Common side effects of Marqibo include: anemia, constipation, neutropenia, and thrombocytopenia. Other side effects include: asthenia, increased serum aspartate aminotransferase, and intestinal obstruction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vincristine liposome: intravenous suspension


Intravenous route (Suspension)

VinCRIStine sulfate liposome is for IV use only and is fatal if given by other routes. Death has occurred with intrathecal use. VinCRIStine sulfate liposome injection has different dosage recommendations than vinCRIStine sulfate injection. Verify drug name and dose before preparation and administration to avoid overdosage.

Side effects requiring immediate medical attention

Along with its needed effects, vincristine liposome (the active ingredient contained in Marqibo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking vincristine liposome:

More common

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • chest pain or tightness
  • chills
  • confusion
  • cough
  • diarrhea
  • dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • lack or loss of strength
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid breathing
  • severe constipation
  • severe vomiting
  • sneezing
  • sore throat
  • stomach pain
  • sweating
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Blue lips, fingernails, or skin
  • bone pain
  • change in muscle reflexes
  • coughing up blood
  • dark urine
  • headache
  • irregular, fast or slow, or shallow breathing
  • joint pain, stiffness, or swelling
  • light-colored stools
  • muscle pain or weakness
  • stomach pain, continuing
  • swelling of the feet or lower legs
  • vomiting
  • weakness of the muscles in your face
  • yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of vincristine liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

  • Redness, pain, or swelling at the injection site

For Healthcare Professionals

Applies to vincristine liposome: intravenous kit


Common (1% to 10%): Hypotension, cardiac arrest, vascular disorder[Ref]


Very common (10% or more): Nausea (52%), diarrhea (37%), decreased appetite (33%)

Common (1% to 10%): Constipation, abdominal pain, ileus/colonic pseudo-obstruction[Ref]


Side effects that have resulted in non-leukemia related deaths: Brain infarct, intracerebral hemorrhage, liver failure, multisystem organ failure, pneumonia and septic shock, respiratory failure, pulmonary hemorrhage, sudden cardiac death[Ref]


Very common (10% or more): Febrile neutropenia (38%), neutropenia (31.3%), anemia (34%), thrombocytopenia (16.9%)

Frequency not reported: Neutropenia, thrombocytopenia[Ref]


Frequency not reported: Increased aspartate aminotransferase, tumor lysis syndrome[Ref]


Frequency not reported: Asthenia, muscular weakness, musculoskeletal pain[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (39%), insomnia (32%)

Common (1% to 10%): Peripheral sensory and motor neuropathy, decreased vibratory sense, facial palsy, hyporeflexia, asthenia[Ref]


Very common (10% or more): Pyrexia (15%), fatigue (12%)[Ref]


Frequency not reported: Mental status changes[Ref]


Common (1% to 10%): Respiratory distress, respiratory failure, pneumonia[Ref]


Common (1% to 10%): Septic shock, staphylococcal bacteremia[Ref]


Frequency not reported: Extravasation tissue injury[Ref]


Frequency not reported: Hepatic toxicity[Ref]


Very common (10% or more): Pyrexia (43%), fatigue (41%)

Frequency not reported: Pain, septic shock, staphylococcal bacteremia[Ref]


1. "Product Information. Marqibo (vinCRIStine liposome)." Talon Therapeutics Inc, South San Francisco,, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.